Identification, Synthesis, and Characterization of Process Related Impurities in the Synthesis of Boc-L-Lys(Boc)-OSu

Protected lysine esters (Boc-L-Lys(Boc)-OSu) an intermediate of high repute in the peptide synthesis and diverse chemical synthetic applications, was the subject of synthetic process development studies, unveiling process-related impurities. These impurities were synthesized, characterized, and iden...

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 61; no. 11; pp. 1710 - 1720
Main Authors Pakhurde, Amit H., Kishore, D. V. P., Kotharkar, Sandeep A.
Format Journal Article
LanguageEnglish
Published HOBOKEN Wiley 01.11.2024
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
synthesis
L-lysine monohydrochloride
process impurities
Boc-L-Lys (Boc)-OSu impurities
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Summary:Protected lysine esters (Boc-L-Lys(Boc)-OSu) an intermediate of high repute in the peptide synthesis and diverse chemical synthetic applications, was the subject of synthetic process development studies, unveiling process-related impurities. These impurities were synthesized, characterized, and identified by different analytical tools, with their retention times verified by HPLC co-injection with commercial products. Detailed discussions ensued on the potential formation pathways and synthetic strategies of these process-related impurities. Process related impurities of Boc-L-Lys(Boc)-OSu.image
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4884