A Practical and Scalable Synthesis of GTx‐134, an IGF‐1R Inhibitor

A practical and scalable synthesis of GTx‐134, a novel small‐molecule inhibitor of insulin‐like growth factor 1 receptor showing antitumor activity in preclinical models of multiple myeloma, is reported.

Saved in:
Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 53; no. 5; pp. 1430 - 1438
Main Authors Liu, Yahu A., Gregor, Vlad E.
Format Journal Article
LanguageEnglish
Published HOBOKEN Wiley 01.09.2016
Wiley Subscription Services, Inc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CANCER
BENZIMIDAZOLE
Online AccessGet full text

Cover

More Information
Summary:A practical and scalable synthesis of GTx‐134, a novel small‐molecule inhibitor of insulin‐like growth factor 1 receptor showing antitumor activity in preclinical models of multiple myeloma, is reported.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2443