Autoregulation of cerebral blood flow after experimental fluid percussion injury of the brain

To test the hypothesis that concussive brain injury autoregulation of cerebral blood flow (CBF), 24 cats were subjected to hemorrhagic hypotension in 10-mm Hg increments while measurements were made of arterial and intracranial pressure, CBF, and arterial blood gases. Eight cats served as controls,...

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Bibliographic Details
Published inJournal of neurosurgery Vol. 53; no. 4; p. 500
Main Authors Lewelt, W, Jenkins, L W, Miller, J D
Format Journal Article
LanguageEnglish
Published United States 01.10.1980
Subjects
Animals
Blood Pressure
Brain Injuries - physiopathology
Cats
Cerebral Hemorrhage - physiopathology
Cerebrovascular Circulation
Homeostasis
Hypotension - physiopathology
Intracranial Pressure
Percussion
Perfusion
Regional Blood Flow
Vascular Resistance
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Summary:To test the hypothesis that concussive brain injury autoregulation of cerebral blood flow (CBF), 24 cats were subjected to hemorrhagic hypotension in 10-mm Hg increments while measurements were made of arterial and intracranial pressure, CBF, and arterial blood gases. Eight cats served as controls, while eight were subjected to mild fluid percussion injury of the brain (1.5 to 2.2 atmospheres) and eight to severe injury (2.8 to 4.8 atmospheres). Injury produced only transient changes in arterial and intracranial pressure, and no change in resting CBF. Impairment of autoregulation was found in injured animals, more pronounced in the severe-injury group. This could not be explained on the basis of intracranial hypertension, hypoxemia, hypercarbia, or brain damage localized to the area of the blood flow electrodes. It is, therefore, concluded that concussive brain injury produces a generalized loss of autoregulation for at least several hours following injury.
ISSN:0022-3085
DOI:10.3171/jns.1980.53.4.0500