Antibiotics Removal during Continuous Renal Replacement Therapy in Septic Shock Patients: Mixed Modality Versus “Expanded Haemodialysis”
Background and Objective Renal replacement therapy (RRT) plays a critical role in antimicrobial removal, particularly for low-molecular-weight drugs with low plasma protein binding, low distribution volume and hydrophilicity. Medium cut-off (MCO) membranes represent a new generation in dialysis tech...
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Published in | Clinical pharmacokinetics Vol. 63; no. 8; pp. 1167 - 1176 |
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Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Cham
Springer International Publishing
01.08.2024
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Background and Objective
Renal replacement therapy (RRT) plays a critical role in antimicrobial removal, particularly for low-molecular-weight drugs with low plasma protein binding, low distribution volume and hydrophilicity. Medium cut-off (MCO) membranes represent a new generation in dialysis technology, enhancing diffusive modality efficacy and increasing the cut-off from 30 to 45 kDa, crucial for middle molecule removal.
This monocentric randomized crossover pilot study aimed to evaluate the impact of continuous haemodialysis with MCO membrane (MCO-CVVHD) on the removal of piperacillin, tazobactam and meropenem compared with continuous veno-venous hemodiafiltration with standard high-flux membrane (HFM-CVVHDF).
Methods
Twenty patients were randomized to undergo MCO-CVVHD followed by HFM-CVVHDF or vice versa. Extraction ratio (ER), effluent clearance (Cl
eff
) and treatment efficiency were assessed at various intervals. Antibiotic nadir plasma levels were measured for both treatment days.
Results
HFM-CVVHDF showed greater ER compared with MCO-CVVHD for meropenem (
β
= − 8.90 (95% CI − 12.9 to − 4.87),
p
< 0.001) and tazobactam (
β
= − 8.29 (95% CI − 13.5 to − 3.08),
p
= 0.002) and Cl
eff
for each antibiotic (meropenem
β
= − 10,206 (95% CI − 14,787 to − 5787),
p
= 0.001); tazobactam (
β
= − 4551 (95% CI − 7781 to − 1322),
p
= 0.012); piperacillin (
β
= − 3913 (95% CI − 6388 to − 1437),
p
= 0.002), even if the carryover effect influenced the Cl
eff
for meropenem and tazobactam. No difference was observed in nadir plasma concentrations or efficiency for any antibiotic. Piperacillin (
β
= − 38.1 (95% CI − 47.9 to − 28.3),
p
< 0.001) and tazobactam (
β
= − 4.45 (95% CI − 6.17 to − 2.72),
p
< 0.001) showed lower nadir plasma concentrations the second day compared with the first day, regardless the filter type.
Conclusion
MCO demonstrated comparable in vivo removal of piperacillin, tazobactam and meropenem to HFM. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
ISSN: | 0312-5963 1179-1926 1179-1926 |
DOI: | 10.1007/s40262-024-01397-w |