Significance of the Expression of Rho-GDP Dissociation Inhibitorβ,γin Lung Squamous Cell Carcinoma and Adenocarcinoma

• Published in: Chinese journal of cancer research Vol. 19; no. 4; pp. 287 - 290
• Main Author: 孙曼妮 李晓倩 周静怡 刘冬明 韩昱晨
• Format: Journal Article
• Language: English
• Published: Department of Clinic Medicine,Basic Medicine College, China Medical University, Shenyang 110011%Department of Medical Biology,Basic Medicine College, China Medical University, Shenyang 110011%Department of Pathology, Basic Medicine College, China Medical University, Shenyang 110011 01.12.2007
• Subjects: 治疗方法; 细胞; 肺癌; 肿瘤; 腺癌; Lung squamous cell carcinoma and adenocarcinoma; RhoC; Rho-GDIγ; Rho-GDIβ
• ISSN: 1000-9604; 1993-0631
• DOI: 10.1007/s11670-007-0287-y

Objective： To study the expression of Rho-GDP dissociation inhibitor β,γ （Rho-GDIβ, Rho-GDIγ） in lung squamous cell carcinoma and adenocarcinoma and its relationship with the expression of RhoC （Ras homologus oncogenes C） and clinicopathologic parameters. Methods： Western blot assay was employed for Rho-GDIβ, Rho-GDIγand RhoC in lung squamous cell carcinoma and adenocarcinoma and non-neoplastic lung tissues of 37 cases with fresh specimens. Results： The study showed that Rho-GDIβ, Rho-GDIγ and RhoC were expressed in lung cancer and non-neoplastic lung tissues, the level in lung cancer tissue was much higher than that in non-neoplastic tissues （P〈0.001）. In lung cancer, the expression of Rho-GDIβwas much higher in patients with lymph node metastasis （P=0.021）, and the expression of Rho-GDIγ was much higher in poorly differentiated tumor than in well-differentiated and moderately differentiated tumor, but both of them were not correlated with other clinicopathologic parameters. The expressions of Rho-GDIβ and Rho-GDIγ were not correlated with the expression of RhoC. Conclusion： In lung cancer, Rho-GDIβand Rho-GDIγ may play a role in the tumorigenesis, Rho-GDIβ may promote metastasis, and Rho-GDIγ may have some relationship with differentiation.