Genetic testing by cancer site: ovary

Approximately 1 in every 4 to 5 women with a diagnosis of ovarian cancer has a hereditary gene mutation that is responsible for the development of her cancer. Identifying women at increased risk of developing ovarian cancer due to a hereditary cancer syndrome can allow for early detection or prevent...

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Bibliographic Details
Published inThe cancer journal (Sudbury, Mass.) Vol. 18; no. 4; p. 320
Main Authors Weissman, Scott M, Weiss, Shelly M, Newlin, Anna C
Format Journal Article
LanguageEnglish
Published United States 01.07.2012
Subjects
Colorectal Neoplasms, Hereditary Nonpolyposis - genetics
DNA-Binding Proteins - genetics
Female
Genes, BRCA1
Genes, BRCA2
Genetic Counseling
Genetic Predisposition to Disease
Genetic Testing
Humans
Neoplastic Syndromes, Hereditary - genetics
Ovarian Neoplasms - diagnosis
Ovarian Neoplasms - genetics
Ovarian Neoplasms - prevention & control
Peutz-Jeghers Syndrome - genetics
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Summary:Approximately 1 in every 4 to 5 women with a diagnosis of ovarian cancer has a hereditary gene mutation that is responsible for the development of her cancer. Identifying women at increased risk of developing ovarian cancer due to a hereditary cancer syndrome can allow for early detection or prevention of not only ovarian cancer, but also other cancers, depending on the causative gene. This review focuses on 3 of the most common hereditary ovarian cancer syndromes, hereditary breast and ovarian cancer syndrome (the BRCA1 and BRCA2 genes), Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer syndrome), and Peutz-Jeghers syndrome, including key features, genetics, and management of these syndromes. In addition, newly discovered genes (eg, RAD51C and RAD51D) linked to ovarian cancer are discussed.
ISSN:1540-336X
DOI:10.1097/PPO.0b013e31826246c2