A Monoclonal Antibody to Viral Glycoprotein Blocks Virus-Immune Effector T Cells Operating at H-2Dd but Not at H-2Kd

Summary A particular monoclonal antibody that binds to the influenza virus HA molecule inhibits HA-specific thymus-derived lymphocytes mediating cytotoxicity in the context of H-2Dd but not of H-2Kd. Another monoclonal antibody blocks both sets of HA-specific effector T cells. This observation, toge...

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Published inThe Journal of immunology (1950) Vol. 123; no. 5; pp. 2438 - 2440
Main Authors Frankel, Mark E, Effros, Rita B, Doherty, Peter C, Gerhard, Walter U
Format Journal Article
LanguageEnglish
Published Am Assoc Immnol 01.11.1979
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Summary:Summary A particular monoclonal antibody that binds to the influenza virus HA molecule inhibits HA-specific thymus-derived lymphocytes mediating cytotoxicity in the context of H-2Dd but not of H-2Kd. Another monoclonal antibody blocks both sets of HA-specific effector T cells. This observation, together with related findings from other laboratories, is considered to support the idea that T cell recognition is directed against some association of viral and H-2 glycoproteins, as proposed in the original formulation of the “altered self” concept.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.123.5.2438