Nicotine Replacement Therapy and Healthy Lifestyle Psychoeducation for Smoking Reduction in Acute Psychiatric Inpatients: A Cluster-Randomized Parallel Study

• Published in: Journal of clinical psychopharmacology Vol. 40; no. 2; p. 149
• Main Authors: Chan, Hung-Yu, Chen, Jiahn-Jyh, Pan, Yi-Ju, Hsu, Chun-Chi
• Format: Journal Article
• Language: English
• Published: United States 01.03.2020
• Subjects: Adult; Behavior Therapy; Female; Healthy Lifestyle; Humans; Inpatients; Male; Mental Disorders; Middle Aged; Nicotine - administration & dosage; Nicotine Chewing Gum; Random Allocation; Smoking Reduction; Substance Withdrawal Syndrome; Tobacco Use Cessation Devices
• ISSN: 1533-712X
• DOI: 10.1097/JCP.0000000000001170

Effectiveness of nicotine replacement therapies in acute psychiatric inpatient settings remains under-researched. The aim of this study was to compare effectiveness and acceptability of 3 different forms of nicotine replacement therapy in achieving smoking reduction among acute psychiatric inpatients. This cluster-randomized, parallel study compared effectiveness and acceptability of nicotine inhalers, nicotine gum, and nicotine patches for smoking reduction in the acute psychiatric inpatient setting. The primary outcome was the exhaled breath carbon monoxide (CO) level change from baseline at weeks 4 and 8. Secondary outcomes included changes in nicotine withdrawal symptoms and psychiatric symptom severity. Three hundred ten inpatients on the acute care wards were randomly assigned to nicotine inhalers (n = 184), gum (n = 71), and patches (n = 55). Only the nicotine inhaler group showed statistically significant reduction in CO level from baseline at both weeks 4 and 8 (P < 0.001 and P = 0.032, respectively). The nicotine inhaler and the patch group showed significant decrease in nicotine withdrawal symptoms from baseline at both weeks 4 and 8. Meanwhile, the nicotine inhaler and the gum group showed significant decrease in psychiatric symptom severity from baseline at both weeks 4 and 8. Post hoc comparisons revealed that the inhaler group had a greater decrease in psychiatric symptom severity compared with the patch group. Nicotine inhalers may be an effective choice for smoking reduction in acute psychiatric inpatient settings given its significant effects on CO level, withdrawal symptoms, and psychiatric symptom severity, particularly during the first 4 weeks of treatment.