Studies of Ca2+ ATPase (SERCA) inhibition

• Published in: Journal of bioenergetics and biomembranes Vol. 37; no. 6; pp. 365 - 368
• Main Authors: Inesi, Giuseppe, Hua, Suming, Xu, Cheng, Ma, Hailun, Seth, Malini, Prasad, Anand M, Sumbilla, Carlota
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.12.2005
• Subjects: Adenosine triphosphatase; Benzene; Binding Sites; Ca2+-transporting ATPase; Calcium (intracellular); Calcium ions; Calcium transport; Calcium-Transporting ATPases - antagonists & inhibitors; Chemical compounds; Enzyme Inhibitors - pharmacology; Gene silencing; Gene Silencing - drug effects; Hydroquinone; RNA, Small Interfering - pharmacology; Thapsigargin

The Ca(2+) transport ATPase of intracellular membranes (SERCA) can be inhibited by a series of chemical compounds such as Thapsigargin (TG), 2,5-di(tert-butyl)hydroquinone (DBHQ) and 1,3-dibromo-2,4,6-tris (methyl-isothio-uronium) benzene (Br(2)-TITU). These compounds have specific binding sites in...