Studies of Ca2+ ATPase (SERCA) inhibition

The Ca(2+) transport ATPase of intracellular membranes (SERCA) can be inhibited by a series of chemical compounds such as Thapsigargin (TG), 2,5-di(tert-butyl)hydroquinone (DBHQ) and 1,3-dibromo-2,4,6-tris (methyl-isothio-uronium) benzene (Br(2)-TITU). These compounds have specific binding sites in...

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Bibliographic Details
Published inJournal of bioenergetics and biomembranes Vol. 37; no. 6; pp. 365 - 368
Main Authors Inesi, Giuseppe, Hua, Suming, Xu, Cheng, Ma, Hailun, Seth, Malini, Prasad, Anand M, Sumbilla, Carlota
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.12.2005
Subjects
Adenosine triphosphatase
Benzene
Binding Sites
Ca2+-transporting ATPase
Calcium (intracellular)
Calcium ions
Calcium transport
Calcium-Transporting ATPases - antagonists & inhibitors
Chemical compounds
Enzyme Inhibitors - pharmacology
Gene silencing
Gene Silencing - drug effects
Hydroquinone
RNA, Small Interfering - pharmacology
Thapsigargin
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Summary:The Ca(2+) transport ATPase of intracellular membranes (SERCA) can be inhibited by a series of chemical compounds such as Thapsigargin (TG), 2,5-di(tert-butyl)hydroquinone (DBHQ) and 1,3-dibromo-2,4,6-tris (methyl-isothio-uronium) benzene (Br(2)-TITU). These compounds have specific binding sites in the ATPase protein, and different mechanisms of inhibition. On the other hand, SERCA gene silencing offers a convenient and specific method for suppression of SERCA activity in cells. The physiological and pharmacological implications of SERCA inhibition are discussed.
ISSN:0145-479X
1573-6881
DOI:10.1007/s10863-005-9472-1