Exploiting iron-binding proteins for drug delivery

Currently, many therapies fail due to an insufficient drug dose reaching the target site and high systemic toxicity. Protein-based drug delivery systems that allow an increase in drug concentration at a specific location in the body or predominantly target malignant cells are promising technologies....

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Published inJournal of physiology and pharmacology : an official journal of the Polish Physiological Society Vol. 70; no. 5
Main Authors Bialasek, M, Kubiak, M, Gorczak, M, Braniewska, A, Kucharzewska-Siembieda, P, Krol, M, Taciak, B
Format Journal Article
LanguageEnglish
Published Poland 01.10.2019
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Summary:Currently, many therapies fail due to an insufficient drug dose reaching the target site and high systemic toxicity. Protein-based drug delivery systems that allow an increase in drug concentration at a specific location in the body or predominantly target malignant cells are promising technologies. Due to the high need for iron in many disorders including various types of cancer, iron-binding proteins: transferrin, ferritin and hemoglobin, are a promising tool as drug carriers. In this review we summarize the characteristics of human iron-binding proteins and present their use in targeted drug delivery strategies.
ISSN:1899-1505
DOI:10.26402/jpp.2019.5.03