microRNAs and thrombo-inflammation: relationship in sight

Thrombo-inflammation is a multifaceted pathologic process involving various cells such as platelets, neutrophils, and monocytes. In recent years, microRNAs have been consistently implicated as regulators of these cells. MicroRNAs play a regulatory role in several platelet receptors that have recentl...

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Bibliographic Details
Published inCurrent opinion in hematology Vol. 31; no. 3; p. 140
Main Authors Águila, Sonia, González-Conejero, Rocío, Martínez, Constantino
Format Journal Article
LanguageEnglish
Published United States 01.05.2024
Subjects
Blood Platelets - pathology
Extracellular Traps
Humans
Inflammation - genetics
Inflammation - pathology
MicroRNAs - genetics
Neutrophils - pathology
Thrombosis - genetics
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Summary:Thrombo-inflammation is a multifaceted pathologic process involving various cells such as platelets, neutrophils, and monocytes. In recent years, microRNAs have been consistently implicated as regulators of these cells. MicroRNAs play a regulatory role in several platelet receptors that have recently been identified as contributing to thrombo-inflammation and neutrophil extracellular trap (NET) formation. In addition, a growing body of evidence has shown that several intracellular and extracellular microRNAs directly promote NET formation. Targeting microRNAs is a promising therapeutic approach to control thrombosis in patients with both infectious and noninfectious inflammatory diseases. Future research efforts should focus on elucidating the specific roles of microRNAs in thrombo-inflammation and translating these findings into tangible benefits for patients.
ISSN:1531-7048
DOI:10.1097/MOH.0000000000000803