A one-pot synthesis of pyrido[2,3-d]- and quinolino[2,3-d]pyrimidines

The in situ formed methylene derivatives of 1,3-dicarbonyl compounds; ethyl cyanoacetate; malononitrile and ketones; react with 6-amino-1,3-dimethyluracil as activated alkenyl derivatives, affording Michael adducts. The adduts simultaneously undergo cyclization to furnish pyrido[2,3-d]- or quinolino...

Full description

Saved in:
Bibliographic Details
Published inHeterocycles Vol. 55; no. 7; pp. 1315 - 1322
Main Authors El-Ahl, AAS, El Bialy, SAA, Ismail, MA
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.07.2001
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
DERIVATIVES
URACILS
Online AccessGet more information

Cover

More Information
Summary:The in situ formed methylene derivatives of 1,3-dicarbonyl compounds; ethyl cyanoacetate; malononitrile and ketones; react with 6-amino-1,3-dimethyluracil as activated alkenyl derivatives, affording Michael adducts. The adduts simultaneously undergo cyclization to furnish pyrido[2,3-d]- or quinolino[2,3-d]pyrimidine derivatives in high yield.
ISSN:0385-5414
DOI:10.3987/com-01-9209