A pinch of salt boosts T cell function

Effector CD8 + T cells with cytotoxic ability are crucial for immunotherapy success. Two studies show that salt (NaCl) supplementation can enhance the effector function of CD8 + T cells and boost their antitumor responses.

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Bibliographic Details
Published inNature immunology Vol. 25; no. 10; pp. 1772 - 1774
Main Authors Hajdu, Karina L., Rousseau, Lorène, Ho, Ping-Chih
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.10.2024
Nature Publishing Group
Subjects
631/250/1619/554/1834
631/250/580
631/45
Antitumor activity
Biomedical and Life Sciences
Biomedicine
Cancer
CD8 antigen
Cytokines
Cytotoxicity
Effector cells
Epigenetics
Immunology
Immunotherapy
Infectious Diseases
Kinases
Lymphocytes
Lymphocytes T
Medical research
Melanoma
Metabolism
News & Views
news-and-views
Salt
Sodium
Sodium chloride
T cell receptors
Tumors
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More Information
Summary:Effector CD8 + T cells with cytotoxic ability are crucial for immunotherapy success. Two studies show that salt (NaCl) supplementation can enhance the effector function of CD8 + T cells and boost their antitumor responses.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-News-3
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ISSN:1529-2908
1529-2916
1529-2916
DOI:10.1038/s41590-024-01946-2