Respiratory Function of Mitochondria in Patients with Coronary Heart Disease with Implantable Cardioverter-Defibrillator
We studied the respiratory activity of mitochondria in peripheral blood leukocytes from 36 patients with coronary heart disease (CHD) and a history of ventricular tachyarrhythmias required cardioverter-defibrillator implantation. The measurements were carried out in incubation buffers with different...
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Published in | Bulletin of experimental biology and medicine Vol. 177; no. 1; pp. 22 - 25 |
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Abstract | We studied the respiratory activity of mitochondria in peripheral blood leukocytes from 36 patients with coronary heart disease (CHD) and a history of ventricular tachyarrhythmias required cardioverter-defibrillator implantation. The measurements were carried out in incubation buffers with different oxidation substrates (succinate and pyruvate-malate mixture). In pyruvate-malate incubation buffer, oxygen consumption rate and respiratory control coefficients in patients with triggered device did not differ significantly from those in patients without cardioverter-defibrillator triggering. At the same time, respiratory control coefficients were below the reference values. In succinate buffer, values of mitochondrial parameters were significantly lower in patients with triggered devices. Our findings indicate that mitochondria of patients with non-triggered cardioverters-defibrillators have better functional and metabolic plasticity. It was concluded that activity of respiratory processes in mitochondria could be an indicator that should be taken into the account when assessing the risk of developing ventricular tachyarrhythmias. |
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AbstractList | We studied the respiratory activity of mitochondria in peripheral blood leukocytes from 36 patients with coronary heart disease (CHD) and a history of ventricular tachyarrhythmias required cardioverter-defibrillator implantation. The measurements were carried out in incubation buffers with different oxidation substrates (succinate and pyruvate-malate mixture). In pyruvate-malate incubation buffer, oxygen consumption rate and respiratory control coefficients in patients with triggered device did not differ significantly from those in patients without cardioverter-defibrillator triggering. At the same time, respiratory control coefficients were below the reference values. In succinate buffer, values of mitochondrial parameters were significantly lower in patients with triggered devices. Our findings indicate that mitochondria of patients with non-triggered cardioverters-defibrillators have better functional and metabolic plasticity. It was concluded that activity of respiratory processes in mitochondria could be an indicator that should be taken into the account when assessing the risk of developing ventricular tachyarrhythmias.We studied the respiratory activity of mitochondria in peripheral blood leukocytes from 36 patients with coronary heart disease (CHD) and a history of ventricular tachyarrhythmias required cardioverter-defibrillator implantation. The measurements were carried out in incubation buffers with different oxidation substrates (succinate and pyruvate-malate mixture). In pyruvate-malate incubation buffer, oxygen consumption rate and respiratory control coefficients in patients with triggered device did not differ significantly from those in patients without cardioverter-defibrillator triggering. At the same time, respiratory control coefficients were below the reference values. In succinate buffer, values of mitochondrial parameters were significantly lower in patients with triggered devices. Our findings indicate that mitochondria of patients with non-triggered cardioverters-defibrillators have better functional and metabolic plasticity. It was concluded that activity of respiratory processes in mitochondria could be an indicator that should be taken into the account when assessing the risk of developing ventricular tachyarrhythmias. We studied the respiratory activity of mitochondria in peripheral blood leukocytes from 36 patients with coronary heart disease (CHD) and a history of ventricular tachyarrhythmias required cardioverter-defibrillator implantation. The measurements were carried out in incubation buffers with different oxidation substrates (succinate and pyruvate-malate mixture). In pyruvate-malate incubation buffer, oxygen consumption rate and respiratory control coefficients in patients with triggered device did not differ significantly from those in patients without cardioverter-defibrillator triggering. At the same time, respiratory control coefficients were below the reference values. In succinate buffer, values of mitochondrial parameters were significantly lower in patients with triggered devices. Our findings indicate that mitochondria of patients with non-triggered cardioverters-defibrillators have better functional and metabolic plasticity. It was concluded that activity of respiratory processes in mitochondria could be an indicator that should be taken into the account when assessing the risk of developing ventricular tachyarrhythmias. |
Author | Batalov, R. E. Korepanov, V. A. Atabekov, T. A. Rebrova, T. Y. Afanasiev, S. A. |
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Cites_doi | 10.1134/S0006297915050089 10.1007/s10517-020-04903-9 10.20538/1682-0363-2023-1-51-56 10.1161/JAHA.114.001289 10.1007/s00239-009-9227-4 10.17116/terarkh20178912103-109 10.18087/cardio.2022.12.n2082 |
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Keywords | mitochondria respiration implantable cardioverter-defibrillator cardiac rhythm disorder |
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References | IrwinJASaunierJLNiederstätterHStroussKMSturkKADiegoliTMBrandstätterAParsonWParsonsTJInvestigation of heteroplasmy in the human mitochondrial DNA control region: a synthesis of observations from more than 5000 global population samplesJ. Mol. Evol.20096855165271:CAS:528:DC%2BD1MXmsVCltrw%3D10.1007/s00239-009-9227-419407924 Bockeria LA, Neminushchiy NM, Mikhaylichenko SI, Novichkov SA, Achkasov EE. Implantable cardioverter defibrillators in the prevention of sudden cardiac death. Ter. Arkhiv. 2017;89(12):103-109. Russian. https://doi.org/10.17116/terarkh20178912103-109 Afanas’ev SA, Muslimova EF, Rebrova TYu, Tsapko LP, Kercheva MA, Golubenko MV. Peculiarities of the functional state of mitochondria of peripheral blood leukocytes in patients with acute myocardial infarction. Bull. Exp. Biol. Med. 2020;169(4):435-437. https://doi.org/10.1007/s10517-020-04903-9 Boytsov SA, Nikulina NN, Yakushin SS, Akinina SA, Furmenko GI. Sudden cardiac death in patients with coronary heart disease: results of the Russian multi-centre epidemiological study of mortality, morbidity, and diagnostics and treatment quality in acute CHD (RESONANCE). Ross. Kardiol. Zh. 2011;(2):59-64. Russian. MerchantFMJonesPWehrenbergSLloydMSSaxonLAIncidence of defibrillator shocks after elective generator exchange following uneventful first battery lifeJ. Am. Heart Assoc.20143610.1161/JAHA.114.001289253853464338723 Korepanov VA, Rebrova TYu, Afanasiev SA. Respiration in isolated cardiomyocytes and microviscosity of their membranes in rats of different ages with heart failure. Byull. Sib. Med. 2023;22(1):51-56. Russian. https://doi.org/10.20538/1682-0363-2023-1-51-56 Lebedeva NB, Talibullin IV, Parfenov PG, Kashtalap VV, Barbarash OL. Long-term outcomes in patients with an implanted cardioverter-defibrillator according to the Kuzbass registry. Kardiologiya. 2022;62(12):57-63. Russian. https://doi.org/10.18087/cardio.2022.12.n2082 Egorova MV, Afanasyev SA. Isolation of mitochondria from cells and tissues of animals and human: modern methodical approaches. Sib. Zh. Klin. Eksper. Med. 2011;26(1-1):22-28. Russian. Eremeev SA, Yaguzhinsky LS. On local coupling of electron transport and ATP-synthesis system in mitochondria. theory and experiment. Biochemistry. 2015;80(5):576-581. https://doi.org/10.1134/S0006297915050089 6123_CR1 FM Merchant (6123_CR4) 2014; 3 6123_CR8 6123_CR9 6123_CR6 JA Irwin (6123_CR5) 2009; 68 6123_CR7 6123_CR2 6123_CR3 |
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SubjectTerms | Aged Biomedical and Life Sciences Biomedicine Cardiac arrhythmia Cardiology Cardiovascular disease Cardiovascular diseases Cell Biology Coronary artery disease Coronary Disease - physiopathology Coronary Disease - therapy Defibrillators Defibrillators, Implantable Female Functional plasticity Genomes Heart Heart diseases Humans Internal Medicine Laboratory Medicine Leukocytes Malates - metabolism Male Medical history Metabolism Middle Aged Mitochondria Mitochondria - metabolism Mitochondria, Heart - metabolism Oxidation Oxygen consumption Oxygen Consumption - physiology Pathology Peripheral blood Phosphorylation Proteins Pyruvic acid Pyruvic Acid - metabolism Respiration Respiratory function Succinic Acid - metabolism Sucrose Tachycardia, Ventricular - physiopathology Tachycardia, Ventricular - therapy Ventricle |
Title | Respiratory Function of Mitochondria in Patients with Coronary Heart Disease with Implantable Cardioverter-Defibrillator |
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