Respiratory Function of Mitochondria in Patients with Coronary Heart Disease with Implantable Cardioverter-Defibrillator

• Published in: Bulletin of experimental biology and medicine Vol. 177; no. 1; pp. 22 - 25
• Main Authors: Korepanov, V. A., Atabekov, T. A., Rebrova, T. Y., Batalov, R. E., Afanasiev, S. A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2024; Springer Nature B.V
• Subjects: Aged; Biomedical and Life Sciences; Biomedicine; Cardiac arrhythmia; Cardiology; Cardiovascular disease; Cardiovascular diseases; Cell Biology; Coronary artery disease; Coronary Disease - physiopathology; Coronary Disease - therapy; Defibrillators; Defibrillators, Implantable; Female; Functional plasticity; Genomes; Heart; Heart diseases; Humans; Internal Medicine; Laboratory Medicine; Leukocytes; Malates - metabolism; Male; Medical history; Metabolism; Middle Aged; Mitochondria; Mitochondria - metabolism; Mitochondria, Heart - metabolism; Oxidation; Oxygen consumption; Oxygen Consumption - physiology; Pathology; Peripheral blood; Phosphorylation; Proteins; Pyruvic acid; Pyruvic Acid - metabolism; Respiration; Respiratory function; Succinic Acid - metabolism; Sucrose; Tachycardia, Ventricular - physiopathology; Tachycardia, Ventricular - therapy; Ventricle; mitochondria respiration; implantable cardioverter-defibrillator; cardiac rhythm disorder
• ISSN: 0007-4888; 1573-8221; 1573-8221
• DOI: 10.1007/s10517-024-06123-x

We studied the respiratory activity of mitochondria in peripheral blood leukocytes from 36 patients with coronary heart disease (CHD) and a history of ventricular tachyarrhythmias required cardioverter-defibrillator implantation. The measurements were carried out in incubation buffers with different oxidation substrates (succinate and pyruvate-malate mixture). In pyruvate-malate incubation buffer, oxygen consumption rate and respiratory control coefficients in patients with triggered device did not differ significantly from those in patients without cardioverter-defibrillator triggering. At the same time, respiratory control coefficients were below the reference values. In succinate buffer, values of mitochondrial parameters were significantly lower in patients with triggered devices. Our findings indicate that mitochondria of patients with non-triggered cardioverters-defibrillators have better functional and metabolic plasticity. It was concluded that activity of respiratory processes in mitochondria could be an indicator that should be taken into the account when assessing the risk of developing ventricular tachyarrhythmias.