Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses

The mammalian SWI/SNF chromatin remodelling complexes are commonly dysregulated in cancer. These complexes contribute to maintaining genome stability through a variety of pathways. Recent research has highlighted an important interplay between genome instability and immune signalling, and evidence s...

Full description

Saved in:
Bibliographic Details
Published inDNA repair Vol. 133; p. 103609
Main Authors Begg, Katheryn A G, Braun, Hanna, Ghaddar, Nagham, Wu, Lillian, Downs, Jessica A
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2024
Subjects
Animals
Chromatin Assembly and Disassembly
DNA Repair
Genomic Instability
Humans
Immunity
Mammals - genetics
Neoplasms - genetics
Neoplasms - metabolism
Nuclear Proteins - metabolism
Transcription Factors - genetics
Transcription Factors - metabolism
PBRM1
Chromatin remodelling
DNA damage
BAF
ARID1A
Double-strand break repair
DNA repair
SMARCA4
PBAF
Immunotherapy
SWI/SNF
CGAS/STING
Neoantigen
Cancer
Online AccessGet full text

Cover

More Information
Summary:The mammalian SWI/SNF chromatin remodelling complexes are commonly dysregulated in cancer. These complexes contribute to maintaining genome stability through a variety of pathways. Recent research has highlighted an important interplay between genome instability and immune signalling, and evidence suggests that this interplay can modulate the response to immunotherapy. Here, we review emerging studies where direct evidence of this relationship has been uncovered in SWI/SNF deficient cells. We also highlight genome maintenance activities of SWI/SNF that could potentially shape immune responses and discuss potential therapeutic implications.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1568-7864
1568-7856
DOI:10.1016/j.dnarep.2023.103609