The liver fluke Opisthorchis felineus: biology, epidemiology and carcinogenic potential

The liver fluke Opisthorchis felineus is a member of the triad of epidemiologically important liver fluke species belonging to the family Opisthorchiidae and the major agent causing opisthorchiasis over a vast territory, covering Russia, Kazakhstan and several European countries. The similarity betw...

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Published inTransactions of the Royal Society of Tropical Medicine and Hygiene Vol. 110; no. 1; pp. 28 - 36
Main Authors Pakharukova, Mariya Y., Mordvinov, Viatcheslav A.
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.01.2016
Subjects
Animals
Bile Duct Neoplasms - etiology
Bile Duct Neoplasms - parasitology
Cholangiocarcinoma - etiology
Cholangiocarcinoma - parasitology
Humans
Life Cycle Stages
Opisthorchiasis - complications
Opisthorchiasis - epidemiology
Opisthorchiasis - parasitology
Opisthorchis - isolation & purification
Opisthorchis - pathogenicity
Prevalence
Siberia - epidemiology
Liver cancer
Liver fluke
Life cycle stages
Russia
Opisthorchis felineus
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Summary:The liver fluke Opisthorchis felineus is a member of the triad of epidemiologically important liver fluke species belonging to the family Opisthorchiidae and the major agent causing opisthorchiasis over a vast territory, covering Russia, Kazakhstan and several European countries. The similarity between the diseases caused by O. felineus and other liver flukes, O. viverrini and Clonorchis sinensis, in clinical manifestations and course suggests that the scenarios of their development and, possibly, complications have much in common. The International Agency for Research on Cancer classified O. viverrini and C. sinensis as group 1 agents and the major factors inducing cholangiocarcinoma in endemic regions. However, a carcinogenic potential of O. felineus is poorly studied. This review characterizes O. felineus, briefs the epidemiological situation in Western Siberia, the world's largest opisthorchiasis focus, and assesses the carcinogenic potential of this liver fluke. The review is based on a comprehensive analysis of the published medical data on opisthorchiasis and its complications in Western Siberia. Results of performed analysis reflect the actual epidemiological situation in opisthorchiasis focus and suggest an association of this disease with bile duct cancer.
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ISSN:0035-9203
1878-3503
DOI:10.1093/trstmh/trv085