Pregnancy in Women With Solid-Organ Transplants: A Review

• Published in: Obstetrical & gynecological survey Vol. 70; no. 6; p. 408
• Main Authors: Durst, Jennifer K, Rampersad, Roxane M
• Format: Journal Article
• Language: English
• Published: United States 01.06.2015
• Subjects: Adult; Allografts - physiology; Contraception - methods; Female; Humans; Immunosuppressive Agents - adverse effects; Infant, Newborn; Lactation - drug effects; Organ Transplantation - adverse effects; Pregnancy; Pregnancy Complications - etiology; Pregnancy Complications - physiopathology; Pregnancy Outcome; Pregnancy, High-Risk - physiology; Premature Birth
• ISSN: 1533-9866
• DOI: 10.1097/OGX.0000000000000194

Advances in solid-organ transplantation have allowed many women to reach reproductive potential, and pregnancy is no longer a rarity for these women. To identify (1) potential complications to allograft function posed by pregnancy, (2) expected perinatal outcomes in women with solid-organ transplants, (3) risks of potential immunosuppressant regimens, (4) safety of lactation, and (5) contraceptive options for women with solid-organ transplants. Single-center, registry data, and previous systematic reviews were evaluated in women with solid-organ transplants to identify the objectives of this review. In addition, recommendations from public health organizations were examined in regard to safety of medications and contraceptive methods. Women with solid-organ transplants are at risk for premature birth, low birth weight, cesarean delivery, and hypertensive disorders of pregnancy. Most immunosuppressant regimens are safe; however, mycophenolate mofetil should be avoided. Lactation with tacrolimus, cyclosporine, azathioprine, and prednisone appears safe. Long-acting reversible contraceptive methods are safe and effective for transplant recipients. Many successful pregnancies have been achieved in women following transplantation; however, optimal perinatal outcomes require stable allograft function. As more women are becoming pregnant after organ transplantation, a review of obstetric recommendations and perinatal outcome is warranted.