Lymphangitis Carcinomatosa in Neck Soft Tissue: Computed Tomography Findings With Emphasis on Differentiation From Cellulitis

• Published in: Journal of computer assisted tomography Vol. 46; no. 1; p. 140
• Main Authors: Kim, Dae Geun, Yoon, Dae Young, Hong, Ji Hyun, Moon, Ji Yoon, Yun, Eun Joo, Kim, Eun Soo, Lee, Yul
• Format: Journal Article
• Language: English
• Published: United States 01.01.2022
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma - diagnostic imaging; Carcinoma - pathology; Cellulitis - diagnostic imaging; Cellulitis - pathology; Diagnosis, Differential; Female; Humans; Lymphangitis - diagnostic imaging; Lymphangitis - pathology; Lymphatic Metastasis - diagnostic imaging; Lymphatic Metastasis - pathology; Male; Middle Aged; Neck - diagnostic imaging; Neck - pathology; Retrospective Studies; Tomography, X-Ray Computed; Young Adult
• ISSN: 1532-3145
• DOI: 10.1097/RCT.0000000000001234

Lymphangitis carcinomatosa (LC) is a rare form of metastasis. The purposes of this study were to evaluate computed tomography (CT) findings associated with LC in neck soft tissue and to determine those that were useful in distinguishing LC from cellulitis. Contrast-enhanced CT images of 26 patients with pathologically confirmed LC (n = 5) and clinically proven cellulitis (n = 21) were reviewed retrospectively. The following CT findings were evaluated and compared between the 2 groups: subcutaneous fat infiltration, enlargement of muscle, thick irregular enhancement of the superficial cervical fascia, grouping of micronodules, focal intramuscular enhancement, localized fluid collection, and nodular skin thickening. Thick irregular enhancement of the superficial cervical fascia (80.0% vs 0%, P < 0.0005), grouping of micronodules (60.0% vs 0%, P < 0.005), and focal intramuscular enhancement (60.0% vs 4.8%, P < 0.05) were significantly more frequent in LC than in cellulitis. Other findings did not show statistical significance between both groups. When soft tissue swelling is present in the neck with either thick irregular enhancement of the superficial cervical fascia, grouping of micronodules, or focal intramuscular enhancement, the possibility of LC should be considered especially in patients with underlying malignancy.