Decrease of mutual information in brain electrical activity of patients with relapsing-remitting multiple sclerosis

The disturbance of cortical communication has been hypothesized as an important factor in the appearance of cognitive impairment in (MS). Cortical communication is quantified here in control subjects and patients with relapsing-remitting multiple sclerosis (RRMS) on the basis of mean coherence in th...

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Published inBehavioural neurology Vol. 27; no. 2; pp. 201 - 212
Main Authors Lenne, Bruno, Blanc, Jean-Luc, Nandrino, Jean-Louis, Gallois, Philippe, Hautecæur, Patrick, Pezard, Laurent
Format Journal Article
LanguageEnglish
Published Netherlands 2013
Subjects
Adult
Atrophy - pathology
Brain - pathology
Brain - physiopathology
Cognition - physiology
Electroencephalography
Female
Functional Laterality - physiology
Humans
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting - pathology
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Multiple Sclerosis, Relapsing-Remitting - psychology
Nerve Net - physiopathology
Neuropsychological Tests
Severity of Illness Index
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Summary:The disturbance of cortical communication has been hypothesized as an important factor in the appearance of cognitive impairment in (MS). Cortical communication is quantified here in control subjects and patients with relapsing-remitting multiple sclerosis (RRMS) on the basis of mean coherence in the δ, θ, α, β and γ bands and using mutual information computed between pairs of bipolar EEG signals recorded during resting condition. Each patient received also a cognitive assessment using a battery of neuropsychological tests specific to cognitive deficits in MS. No difference was observed for the coherence indices whereas inter-hemispheric and right hemisphere mutual information is significantly lower in patients with MS than in control subjects. Moreover, inter-hemispheric mutual information decrease significantly with illness duration and right mutual information differentiate cognitively deficient and non-deficient patients. Mutual information allows to quantify the cortical communication in patients with RRMS and is related to clinical characteristics. Cortical communication quantified in a resting state might be a potential marker for the neurological damage induced by RRMS.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0953-4180
1875-8584
DOI:10.1155/2013/627529