Peripheral Ulcerative Keratitis Associated With Lichen Planus

• Published in: Cornea Vol. 42; no. 11; p. 1458
• Main Authors: Neo, Yan Ning, Farwana, Reem, Ahmoye, Sarah, Vasquez-Perez, Alfonso
• Format: Journal Article
• Language: English
• Published: United States 01.11.2023
• ISSN: 1536-4798
• DOI: 10.1097/ICO.0000000000003323

The aim of this study was to report a case of peripheral ulcerative keratitis (PUK) associated with lichen planus. A 42-year-old woman with histological confirmation of lichen planus from an oral buccal mucosa biopsy presented with bilateral peripheral stromal thinning and an epithelial defect, in keeping with PUK. All screening for known causes of PUK were negative, and lichen planus was presumed as the etiological factor. Oral prednisolone 1 mg/kg was initiated, alongside topical steroids and topical ciclosporin. The PUK resolved after 3 months, and a slow-tapering regimen of oral prednisolone was needed to prevent a relapse of ocular surface inflammation. Topical steroids were also tapered and discontinued after 5 months, and the ocular surface remained stable with topical ciclosporin with no relapse after 1 year. Ocular manifestations of lichen planus are rare and mostly involve the conjunctiva; however, PUK might also develop, presumably due to its similar mechanisms with other T-cell autoimmune diseases. Systemic immunosuppression is required initially but further control of the ocular surface can be achieved successfully with topical ciclosporin.