Systematic review and recommendations for re-irradiation for intraprostatic radiorecurrent prostate cancer after definitive radiation therapy

• Published in: World journal of urology Vol. 42; no. 1; p. 520
• Main Authors: Saripalli, Anjali L., Venkatesulu, Bhanu Prasad, Nickols, Nicholas G., Valle, Luca F., Harkenrider, Matthew M., Kishan, Amar U., Solanki, Abhishek A.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 12.09.2024; Springer Nature B.V
• Subjects: Biopsy; Brachytherapy; Brachytherapy - methods; Cryotherapy; Electroporation; Humans; Male; Medicine; Medicine & Public Health; Neoplasm Recurrence, Local - radiotherapy; Nephrology; Oncology; Practice Guidelines as Topic; Prostate cancer; Prostatectomy; Prostatic Neoplasms - radiotherapy; Radiation therapy; Radiosurgery - methods; Re-Irradiation - methods; Salvage Therapy - methods; Systematic review; Topic Paper; Urology; Re-irradiation; Stereotactic body radiotherapy; Salvage local therapy; High dose rate brachytherapy; Prostate cancer; Radiorecurrence
• ISSN: 1433-8726; 0724-4983; 1433-8726
• DOI: 10.1007/s00345-024-05205-9

Purpose Intraprostatic recurrence (IRR) of prostate cancer after radiation therapy is increasingly identified. Our objective was to review the literature to determine the optimal workup for identifying IRR, the management options, and practical considerations for the delivery of re-irradiation as salvage local therapy. Methods We performed a systematic review of available publications and ongoing studies on the topics of IRR, with a focus on salvage re-irradiation. Results Work up of biochemically recurrent prostate cancer includes PSMA PET/CT and multiparametric MRI, followed by biopsy to confirm IRR. Management options include continued surveillance, palliative hormonal therapy, and salvage local therapy. Salvage local therapy can be delivered using re-irradiation with low dose rate brachytherapy, high dose rate (HDR) brachytherapy, and stereotactic body radiotherapy (SBRT), as well as non-radiation modalities, such as cryotherapy, high-intensity focused ultrasound, irreversible electroporation and radical prostatectomy. Data demonstrate that HDR brachytherapy and SBRT have similar efficacy compared to the other salvage local therapy modalities, while having more favorable side effect profiles. Recommendations for radiation therapy planning and delivery using HDR and SBRT based on the available literature are discussed. Conclusion Salvage re-irradiation is safe and effective and should be considered in patients with IRR.