Structure–function coupling in macroscale human brain networks

• Published in: Nature reviews. Neuroscience Vol. 25; no. 10; pp. 688 - 704
• Main Authors: Fotiadis, Panagiotis, Parkes, Linden, Davis, Kathryn A., Satterthwaite, Theodore D., Shinohara, Russell T., Bassett, Dani S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2024; Nature Publishing Group
• Subjects: 631/378; 631/378/1689; 631/378/3920; Animal Genetics and Genomics; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Brain; Brain - physiology; Brain architecture; Brain Mapping; Cognition - physiology; Cognitive ability; Computational neuroscience; Connectome - methods; Functional anatomy; Humans; Nerve Net - physiology; Neural networks; Neural Pathways - physiology; Neurobiology; Neurological complications; Neurosciences; Review Article; Reviews; Structure-Activity Relationship; Structure-function relationships; Substantia alba; White Matter - anatomy & histology; White Matter - physiology
• ISSN: 1471-003X; 1471-0048; 1471-0048; 1469-3178
• DOI: 10.1038/s41583-024-00846-6

Precisely how the anatomical structure of the brain gives rise to a repertoire of complex functions remains incompletely understood. A promising manifestation of this mapping from structure to function is the dependency of the functional activity of a brain region on the underlying white matter architecture. Here, we review the literature examining the macroscale coupling between structural and functional connectivity, and we establish how this structure–function coupling (SFC) can provide more information about the underlying workings of the brain than either feature alone. We begin by defining SFC and describing the computational methods used to quantify it. We then review empirical studies that examine the heterogeneous expression of SFC across different brain regions, among individuals, in the context of the cognitive task being performed, and over time, as well as its role in fostering flexible cognition. Last, we investigate how the coupling between structure and function is affected in neurological and psychiatric conditions, and we report how aberrant SFC is associated with disease duration and disease-specific cognitive impairment. By elucidating how the dynamic relationship between the structure and function of the brain is altered in the presence of neurological and psychiatric conditions, we aim to not only further our understanding of their aetiology but also establish SFC as a new and sensitive marker of disease symptomatology and cognitive performance. Overall, this Review collates the current knowledge regarding the regional interdependency between the macroscale structure and function of the human brain in both neurotypical and neuroatypical individuals. How the complex functionality of the human brain depends on its underlying white matter architecture is incompletely understood. In this Review, Fotiadis et al. synthesize the heterogeneous macroscale expression of normative structure–function coupling and then discuss how it is affected in neurological and psychiatric conditions.