Antihypertensive activity of Enterococcus faecalis FK-23 preparation in spontaneously hypertensive rats

• Published in: Nihon Eiyō, Shokuryō Gakkai shi Vol. 45; no. 6; pp. 519 - 522
• Main Authors: Shimada, T. (Nichinichi Food Co. Ltd., Oyamada, Mie (Japan)), Iwatani, K, Yanagisawa, T, Kawai, Y, Abe, S, Yamaguchi, H
• Format: Journal Article
• Language: Japanese
• Published: Japan Society of Nutrition and Food Science 1992
• Subjects: BLOOD PRESSURE; ENTEROCOCCUS; Enterococcus faecalis; INHIBICION; INHIBITION; oral administration; PRESION SANGUINEA; PRESSION SANGUINE; RAT; RATA; RATS; repression of cardiac hypertrophy; SHR
• ISSN: 0287-3516; 1883-2849
• DOI: 10.4327/jsnfs.45.519

The activity of heat-treated cells of Enterococcus faecalis FK-23 (FK-23 preparation) isolated fromthe intestine of a healthy human on systolic blood pressure (SBP) was investigated in spontaneously hypertensive rats (SHR). A significant reduction of high SBP was observed after oral administration of the FK-23 preparation for 7 days at 60 or 120mg/day·rat. SBP ramained blow 200-210mmHg, which was significantly lower than that of the control group (220-230mmHg), over 21 consecutive days of oral administration (p<0.05). This antihypertensive activity was dose-dependent, and the SBP rose again to the control level 14 days after cessation of FK-23 administration. Twenty-eight days of FK-23 administration at 120mg/day·rat followed by 270 days at 240mg/day·rat resulted in an uninterrupted reduction of high SBP. At autopsy, the control group had myocardial hypertrophy whereas the FK-23 preparation-treated group did not. These data indicate that oral administration of this FK-23 preparation may reduce SBP dosedependently over a long period and may prevent the accompanying myocardial hypertrophy.