Development of a verified osteoarthritis risk scale based on a cross-sectional study of clinical and anamnestic parameters and pharmacological anamnesis of patients

• Published in: Farmakoèkonomika (Moskva. Online) Vol. 16; no. 1; pp. 70 - 79
• Main Authors: Torshin, I. Yu, Lila, А. М., Zagorodniy, N. V., Nazarenko, А. G., Tkacheva, О. N., Dudinskaya, Е. N., Alekseeva, L. I., Taskina, Е. А., Sarvilina, I. V., Shavlovskaya, О. А., Danilov, A. B., Minasov, Т. B., Galustyan, А. N., Malyavskaya, S. I., Gromov, А. N., Egorova, Е. Yu, Vasilyeva, L. V., Evstratova, E. F., Gogoleva, I. V., Fedotova, L. E., Udovika, М. I., Maximov, V. A., Povzun, А. S., Gromova, О. А.
• Format: Journal Article
• Language: English; Russian
• Published: IRBIS LLC 01.04.2023
• Subjects: joint pathology; osteoarthritis; osteoarthritis prevention; osteoarthritis risk assessment scale; symptomatic slow-acting drugs for osteoarthritis; sysadoa; topological recognition theory
• ISSN: 2070-4909; 2070-4933
• DOI: 10.17749/2070-4909/farmakoekonomika.2023.158

Objective: the development and verification of a scale for identifying patients at high risk of osteoarthritis (OA). Material and methods. The results of the analysis of a sample of patients aged 35–90 years from the database of the Institute of Trace Elements ( n =3440), which included information on clinical and anamnestic, diagnostic parameters and pharmacotherapy of patients, including patients with OA ( n =107), are presented. To analyze information about patients, modern methods of data analysis proposed within the topological theory of pattern recognition were used. Results. Based on the analysis of the sample, a 100-point scale of 27 points was developed which allows to identify patients at high risk of OA (sensitivity 88%, specificity 100%). For patients with high scores on the scale, a kind of “preemptive” prescription of symptomatic slowacting drugs for osteoarthritis (SySADOA) based on highly purified substances of chondroitin sulfate (CS) and glucosamine sulfate (GS) is promising. The evidence for CS/GS is extensive and has been reviewed previously. Conclusion. Early adoption of preventive measures (including the usage of SySADOA – CS/GS) in patients with a high score on the developed scale may reduce the risk of OA.