Meta-analysis of clinical trials of osteoarthritis treatment effectiveness with Chondroguard

• Published in: Farmakoèkonomika (Moskva. Online) Vol. 13; no. 4; pp. 388 - 399
• Main Authors: Torshin, I. Yu, Lila, A. M., Naumov, A. V., Kochish, A. Yu, Alekseeva, L. I., Taskina, E. A., Sarvilina, I. V., Galustyan, A. N., Gromov, A. N., Khadzhidis, A. K., Vasilieva, L. V., Yevstratova, E. F., Udovika, M. I., Gromova, O. A.
• Format: Journal Article
• Language: English; Russian
• Published: IRBIS LLC 07.02.2021
• Subjects: chondroguard; chondroitin sulfate; data analysis; evidence-based medicine; osteoarthritis
• ISSN: 2070-4909; 2070-4933
• DOI: 10.17749/2070-4909/farmakoekonomika.2020.066

Aim. A meta-analysis of 8 controlled studies (n=771, age 53.6±6.2 years) of tie use of tie Chondroguard (100 mg i.m. first 3 injections, from tie 4th injection - 200 mg i.m., EOD, course 20-30 injections) in the complex therapy of osteoarthritis (OA).Materials and Methods. Tie meta-analysis according to tie fixed-effects model included all published clinical studies on tie efficacy and safety of the CG drug in OA). The effectiveness of therapy was assessed using the VAS, Lequesne, WOMAC scales/indices. For each study, information was collected on 23 features. Data analysis was carried out using the MEDSTUDY and "R" software packages.Results. Meta-analysis confirmed significant associations between the use of Chondroguard (CG. and pain reduction assessed by the visual analog scale (V)S. - CG: a decrease in pain intensity by -28.3 points, control: -11.6; p=0.042. There was a significant reduction in pain according to VAS at night (CG: -20.1; control: -9.9; p=0.05018., while sitting or lying down (CG: -15.5; control: -7.6; p=0.01656., when walking (CG: -28.2; control: -17.0; p=0.04957). The use of CG led to a significant decrease in the scores of the Lequesne index (CG: -4.3; control: -1.4; p=0.0349., and of the WOMAC index (CG: -338.4; control: -219.8; p=0.004., including WOMAC "function" (CG: -247.8; control: -96; p=0.0027., and WOMAC "stiffness" (CG: -25.4; control: -11.2; p=0.0462.. The incidence of side effects did not differ significantly from the control.Conclusion. Chondroguard is an effective treatment for osteoarthritis and has a good safety profile.