Alcohol dehydrogenase controls the flux from ethanol into lipids in Drosophila larvae. A 13C NMR study

The dependence of the flux in the alcohol-degrading pathway on the activity of alcohol dehydrogenase was investigated in Drosophila larvae. Third-instar larvae were supplied with [2-13C]ethanol as a dietary carbon source. Specific carbon enrichments in de novo synthesized fatty acids were determined...

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Published inThe Journal of biological chemistry Vol. 266; no. 32; pp. 21399 - 21403
Main Authors FRERIKSEN, A, SEYKENS, D, SCHARLOO, W, HEINSTRA, P. W. H
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Society for Biochemistry and Molecular Biology 15.11.1991
Subjects
Alcohol Dehydrogenase - genetics
Alcohol Dehydrogenase - metabolism
Animals
Biological and medical sciences
Carbon Isotopes
Cell metabolism, cell oxidation
Cell physiology
Drosophila - genetics
Drosophila - metabolism
Ethanol - metabolism
Fundamental and applied biological sciences. Psychology
Genotype
Isoenzymes - genetics
Isoenzymes - metabolism
Kinetics
Larva
Lipid Metabolism
Magnetic Resonance Spectroscopy - methods
Molecular and cellular biology
Ethanol
Enzyme
Insecta
Lipids
NMR spectrometry
Alcohol dehydrogenase
Metabolism
Fatty acids
Drosophilidae
Enzymatic activity
Arthropoda
Invertebrata
Drosophila melanogaster
Diptera
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Abstract The dependence of the flux in the alcohol-degrading pathway on the activity of alcohol dehydrogenase was investigated in Drosophila larvae. Third-instar larvae were supplied with [2-13C]ethanol as a dietary carbon source. Specific carbon enrichments in de novo synthesized fatty acids were determined in vitro by means of 13C nuclear magnetic resonance spectroscopy. Carbon fluxes deduced from these enrichment patterns were correlated with the in vitro alcohol dehydrogenase activities in three different Adh genotypes in seven different strains. The flux control coefficient for alcohol dehydrogenase was shown to be approximately 1.0. This indicates that the alcohol dehydrogenase gene-enzyme system in Drosophila larvae can be a major target of natural selection.
AbstractList The dependence of the flux in the alcohol-degrading pathway on the activity of alcohol dehydrogenase was investigated in Drosophila larvae. Third-instar larvae were supplied with [2-13C]ethanol as a dietary carbon source. Specific carbon enrichments in de novo synthesized fatty acids were determined in vitro by means of 13C nuclear magnetic resonance spectroscopy. Carbon fluxes deduced from these enrichment patterns were correlated with the in vitro alcohol dehydrogenase activities in three different Adh genotypes in seven different strains. The flux control coefficient for alcohol dehydrogenase was shown to be approximately 1.0. This indicates that the alcohol dehydrogenase gene-enzyme system in Drosophila larvae can be a major target of natural selection.
The dependence of the flux in the alcohol-degrading pathway on the activity of alcohol dehydrogenase was investigated in Drosophila larvae. Third-instar larvae were supplied with [2-13C]ethanol as a dietary carbon source. Specific carbon enrichments in de novo synthesized fatty acids were determined in vitro by means of 13C nuclear magnetic resonance spectroscopy. Carbon fluxes deduced from these enrichment patterns were correlated with the in vitro alcohol dehydrogenase activities in three different Adh genotypes in seven different strains. The flux control coefficient for alcohol dehydrogenase was shown to be approximately 1.0. This indicates that the alcohol dehydrogenase gene-enzyme system in Drosophila larvae can be a major target of natural selection.
Author A Freriksen
P W Heinstra
W Scharloo
D Seykens
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Issue 32
Keywords Ethanol
Enzyme
Insecta
Lipids
NMR spectrometry
Alcohol dehydrogenase
Metabolism
Fatty acids
Drosophilidae
Enzymatic activity
Arthropoda
Invertebrata
Drosophila melanogaster
Diptera
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Snippet The dependence of the flux in the alcohol-degrading pathway on the activity of alcohol dehydrogenase was investigated in Drosophila larvae. Third-instar larvae...
The dependence of the flux in the alcohol-degrading pathway on the activity of alcohol dehydrogenase was investigated in Drosophila larvae. Third-instar larvae...
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SubjectTerms Alcohol Dehydrogenase - genetics
Alcohol Dehydrogenase - metabolism
Animals
Biological and medical sciences
Carbon Isotopes
Cell metabolism, cell oxidation
Cell physiology
Drosophila - genetics
Drosophila - metabolism
Ethanol - metabolism
Fundamental and applied biological sciences. Psychology
Genotype
Isoenzymes - genetics
Isoenzymes - metabolism
Kinetics
Larva
Lipid Metabolism
Magnetic Resonance Spectroscopy - methods
Molecular and cellular biology
Title Alcohol dehydrogenase controls the flux from ethanol into lipids in Drosophila larvae. A 13C NMR study
URI http://www.jbc.org/content/266/32/21399.abstract
https://www.ncbi.nlm.nih.gov/pubmed/1939174
https://search.proquest.com/docview/72450107
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