Alcohol dehydrogenase controls the flux from ethanol into lipids in Drosophila larvae. A 13C NMR study
The dependence of the flux in the alcohol-degrading pathway on the activity of alcohol dehydrogenase was investigated in Drosophila larvae. Third-instar larvae were supplied with [2-13C]ethanol as a dietary carbon source. Specific carbon enrichments in de novo synthesized fatty acids were determined...
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Published in | The Journal of biological chemistry Vol. 266; no. 32; pp. 21399 - 21403 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
American Society for Biochemistry and Molecular Biology
15.11.1991
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Abstract | The dependence of the flux in the alcohol-degrading pathway on the activity of alcohol dehydrogenase was investigated in Drosophila
larvae. Third-instar larvae were supplied with [2-13C]ethanol as a dietary carbon source. Specific carbon enrichments in de
novo synthesized fatty acids were determined in vitro by means of 13C nuclear magnetic resonance spectroscopy. Carbon fluxes
deduced from these enrichment patterns were correlated with the in vitro alcohol dehydrogenase activities in three different
Adh genotypes in seven different strains. The flux control coefficient for alcohol dehydrogenase was shown to be approximately
1.0. This indicates that the alcohol dehydrogenase gene-enzyme system in Drosophila larvae can be a major target of natural
selection. |
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AbstractList | The dependence of the flux in the alcohol-degrading pathway on the activity of alcohol dehydrogenase was investigated in Drosophila larvae. Third-instar larvae were supplied with [2-13C]ethanol as a dietary carbon source. Specific carbon enrichments in de novo synthesized fatty acids were determined in vitro by means of 13C nuclear magnetic resonance spectroscopy. Carbon fluxes deduced from these enrichment patterns were correlated with the in vitro alcohol dehydrogenase activities in three different Adh genotypes in seven different strains. The flux control coefficient for alcohol dehydrogenase was shown to be approximately 1.0. This indicates that the alcohol dehydrogenase gene-enzyme system in Drosophila larvae can be a major target of natural selection. The dependence of the flux in the alcohol-degrading pathway on the activity of alcohol dehydrogenase was investigated in Drosophila larvae. Third-instar larvae were supplied with [2-13C]ethanol as a dietary carbon source. Specific carbon enrichments in de novo synthesized fatty acids were determined in vitro by means of 13C nuclear magnetic resonance spectroscopy. Carbon fluxes deduced from these enrichment patterns were correlated with the in vitro alcohol dehydrogenase activities in three different Adh genotypes in seven different strains. The flux control coefficient for alcohol dehydrogenase was shown to be approximately 1.0. This indicates that the alcohol dehydrogenase gene-enzyme system in Drosophila larvae can be a major target of natural selection. |
Author | A Freriksen P W Heinstra W Scharloo D Seykens |
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Keywords | Ethanol Enzyme Insecta Lipids NMR spectrometry Alcohol dehydrogenase Metabolism Fatty acids Drosophilidae Enzymatic activity Arthropoda Invertebrata Drosophila melanogaster Diptera |
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Snippet | The dependence of the flux in the alcohol-degrading pathway on the activity of alcohol dehydrogenase was investigated in Drosophila
larvae. Third-instar larvae... The dependence of the flux in the alcohol-degrading pathway on the activity of alcohol dehydrogenase was investigated in Drosophila larvae. Third-instar larvae... |
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SubjectTerms | Alcohol Dehydrogenase - genetics Alcohol Dehydrogenase - metabolism Animals Biological and medical sciences Carbon Isotopes Cell metabolism, cell oxidation Cell physiology Drosophila - genetics Drosophila - metabolism Ethanol - metabolism Fundamental and applied biological sciences. Psychology Genotype Isoenzymes - genetics Isoenzymes - metabolism Kinetics Larva Lipid Metabolism Magnetic Resonance Spectroscopy - methods Molecular and cellular biology |
Title | Alcohol dehydrogenase controls the flux from ethanol into lipids in Drosophila larvae. A 13C NMR study |
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