Estrogens and brain

Recent data upon molecular mechanisms of pleiotropic action of estrogens in human brain is presented in the article. Given detailed descriptions of properties of classical and membrane bound estradiol receptors, that maintain gene expression regulation, modulation of neurotransmittent systems and si...

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Bibliographic Details
Published inVestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 2; p. 48
Main Authors Kareva, E N, Oleĭnikova, O M, Panov, V O, Shimanovskiĭ, N L, Skvortsova, V I
Format Journal Article
LanguageRussian
Published Russia (Federation) 2012
Subjects
Apoptosis
Blood Vessels - metabolism
Brain - blood supply
Brain - metabolism
Estradiol - metabolism
Estrogens - metabolism
Gene Expression Regulation
Humans
Inflammation
Neurogenesis
Neurons - metabolism
Neuroprotective Agents
Receptors, Estradiol - classification
Receptors, Estradiol - genetics
Receptors, Estradiol - metabolism
Receptors, Estrogen - genetics
Receptors, Estrogen - metabolism
Signal Transduction
Synaptic Transmission
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Summary:Recent data upon molecular mechanisms of pleiotropic action of estrogens in human brain is presented in the article. Given detailed descriptions of properties of classical and membrane bound estradiol receptors, that maintain gene expression regulation, modulation of neurotransmittent systems and signal cascade activation in neuronal cells. Data upon regional distribution of estradiol receptor subtypes in the brain, their participation in main cell population function control (including progenitor cells) is given. Special attention is paid to estrogen participation in neurogenesis, inflammation and apoptosis regulation in central nervous system; in the control of formation and functioning of cerebral vessels.
ISSN:0869-6047
DOI:10.15690/vramn.v67i2.122