Attenuation of visceral pain in mice by the essential oil from Vanillosmopsis arborea bark

• Published in: Revista dor Vol. 12; no. 1; pp. 46 - 49
• Main Authors: Leite, Gerlânia de Oliveira, Sampaio, Renata Souza, Leite, Laura Hévila Inocêncio, Menezes, Irwin Rose Alencar de, Costa, José Galberto Martins da, Campos, Adriana Rolim
• Format: Journal Article
• Language: English; Portuguese
• Published: Sociedade Brasileira para o Estudo da Dor 01.03.2011
• Subjects: CLINICAL NEUROLOGY; CRITICAL CARE MEDICINE; dor visceral; NEUROSCIENCES; vanillosmopsis arborea; óleo essencial; Dor visceral; Óleo essencial; Essential oil; Visceral pain; Vanillosmopsis arborea
• ISSN: 2317-6393; 1806-0013; 2317-6393
• DOI: 10.1590/S1806-00132011000100010

BACKGROUND AND OBJECTIVES: Vanillosmopsis arborea Baker (Asteraceae) has high economic value and anti-inflammatory properties due the presence of alpha-bisabolol in its bark essential oil. Keeping in view the high content of α-bisabolol in Vanillosmopsis arborea (EOVA) bark essential oil, the aim of our study was to determine whether EOVA mitigates viscer METHOD: Mice (n = 8) were pretreated orally with EOVA (100, 200 e 400 mg/kg) or vehicle, and pain-related behavioral responses to intraperitoneal cyclophosphamide (CPM 400 mg/kg), intracolonic mustard oil (MO 0.75%) or capsaicin (CAP 0.3%) were analyzed. RESULTS: Animals that received CFM, OM or CAP presented spontaneous nociceptive behaviors that were significantly suppressed by EOVA. CONCLUSION: These findings point to visceral antinociceptive properties of EOVA suggesting the potential use of Vanillosmopsis arborea to treat pain associated to gastrointestinal disorders.