Strategies for Inducing and Validating Zinc Deficiency and Zinc Repletion

Given the growing interest in the role of zinc in the onset and progression of diseases, there is a crucial demand for reliable methods to modulate zinc homeostasis. Using a dietary approach, we provide validated strategies to alter whole-body zinc in mice, applicable across species. For confirmatio...

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Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 326; no. 6; pp. H1396 - H1401
Main Authors Wenegieme, Tara-Yesomi, Elased, Dalia, McMichael, Kelia E, Rockwood, Jananie, Hasrat, Khanzada, Ume, Adaku C, Marshall, Andrea G, Neikirk, Kit, Kirabo, Annet, Elased, Khalid M, Hinton, Jr, Antentor, Williams, Clintoria R
Format Journal Article
LanguageEnglish
Published United States 01.06.2024
Subjects
Zinc Homeostasis
In vivo
zinc status
Zinc Deficiency
Zinc Repletion
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Summary:Given the growing interest in the role of zinc in the onset and progression of diseases, there is a crucial demand for reliable methods to modulate zinc homeostasis. Using a dietary approach, we provide validated strategies to alter whole-body zinc in mice, applicable across species. For confirmation of zinc status, animal growth rates as well as plasma and urine zinc levels were evaluated. The accessible and cost-effective methodology outlined will increase scientific rigor, ensuring reproducibility in studies exploring the impact of zinc deficiency and repletion on the onset and progression of diseases.
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ISSN:0363-6135
1522-1539
1522-1539
DOI:10.1152/ajpheart.00025.2024