Cordyceps militaris fermentation changes the flavor and chemical profiles of Lu’an GuaPian green tea with fat-lowering and anti-aging activities

• Published in: Microchemical journal Vol. 201; p. 110676
• Main Authors: Ke, Jia-Ping, Zhang, Yuan-Yuan, Li, Jia-Yi, Wu, Hao-Yue, Yu, Jing-Ya, Chen, Chen-Hui, Yang, Yi, Wang, Wei, Hu, Fenglin, Bao, Guan-Hu
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2024
• Subjects: Caenorhabditis elegans; Cordyceps militaris; Fat lowering; Lifespan; Lu’an GuaPian tea; Fat lowering; CFT; Caenorhabditis elegans; RT; Lu’an GuaPian tea; Cordyceps militaris; OPLS-DA; SSF; LGPT; Lifespan
• ISSN: 0026-265X; 1095-9149
• DOI: 10.1016/j.microc.2024.110676

•Forty critical compounds were identified through MS2 based GNPS matching.•SSF-LGPT significantly lowered lipid content of C.elegans.•SSF-LGPT prolonged the lifespan and healthspan of C. elegans,•SSF-LGPT fermented on the 10th day was the optimum product. Microbial tea products are widely welcomed for their unique quality and characteristics. In this study, Cordyceps militaris (C. militaris), a medicinal and edible fungus, was used to ferment Lu’an GuaPian tea (LGPT) by solid-state fermentation (SSF) and thus developed a new deeply processed tea product (SSF-LGPT) with less bitterness and a distinct herbal aroma. SSF-LGPT (100 μg/mL) showed α-glucosidase inhibitory activity and significantly lowered fat content (34 % inhibition rate) in Caenorhabditis elegans (C. elegans). SSF-LGPT also exhibited antioxidant activity in vitro, prolonged the lifespan, delayed the age-related decline of phenotype, and enhanced stress resistance to heat, oxidative stress, and UV irradiation in C. elegans. Together, C. militaris fermentation of LGPT improves the flavor, hypoglycemic and fat-lowering activities. This study provides a new alternative approach to comprehensively utilize resourceful green tea via C. militaris fermentation.