The effect of sleep disorders on quality of life in patients with epilepsy: A multicenter study from Turkey

• Published in: Epilepsy & behavior Vol. 150; p. 109568
• Main Authors: Akdağ, Gönül, Canbaz Kabay, Sibel, Bican Demir, Aylin, Ergin Bakar, Ebru, Koç, Güray, Üstün Özek, Sibel, Küçük, Ahmet, Ünsal, Miraç Ayşen, Neyal, Abdurrahman, Florentina Ateş, Miruna, Çelik, Havva Tuğba, Kılıçparlar Cengiz, Emine, Kutlu, Gülnihal, Ağırcan, Dilek, Karacan Gölen, Meltem, Bek, Semai, Çınar, Nilgün, Sahin, Sevki, Şişman Bayar, Aysel Büşra, Terzi, Murat, Kendirli Aslan, Sude, Kenar, Safiye Gül, Kutluhan, Süleyman, Ekmekyapar Fırat, Yasemin, Yılmaz Okuyan, Dilek, Bayar, Muhammet Duran, Mert Atmaca, Murat, Yalçın, Destina, Genç, Fatma, Köse Leba, Leyla, Yılmaz, Buket, Eren, Fettah, Bolu, Naci Emre, Keskin Güler, Selda, Akıncı, Tuba, Reyhani, Aylin, Yıldırım Sitembölükbaşı, Neslişah, Türkmen, Nur, Karşıdağ, Sibel, Velioğlu, Sibel K, Demir, Ayşegül, Haytı, Barış, Hasırcı Bayır, Buse Rahime, Ezgi Uçan Tokuç, Firdevs, Demir, Göksemin, Çakmakçı, Güngör, Özkan, Hülya, Bulut, Onur, Kesim Şahin, Özlem, Sürmeli, Reyhan, Tekin, Selma, Sarıoğlu, Şerife Gizem, Gesoğlu Demir, Tülin, Akkoyun Arıkan, Fatma, Çetiner, Mustafa
• Format: Journal Article
• Language: English
• Published: United States 01.01.2024
• Subjects: Epilepsy - complications; Female; Humans; Male; Quality of Life; Sleep; Sleep Initiation and Maintenance Disorders - complications; Sleep Wake Disorders - etiology; Surveys and Questionnaires; Turkey - epidemiology; Turkey; Sleep quality; Excessive daytime sleepiness; Quality of life in epilepsy; Insomnia
• ISSN: 1525-5050; 1525-5069
• DOI: 10.1016/j.yebeh.2023.109568

We aimed to investigate sleep disorders in patients with epilepsy (PWE) and to investigate the effects of sleep disorders on quality of life. In our multicenter study conducted in Turkey, 1358 PWE were evaluated. The demographic and clinical data of the patients were recorded. The Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI), and Quality of Life in Epilepsy Inventory-10 (QOLIE-10) were administered. The mean age of 1358 patients was 35.92 ± 14.11 (range, 18-89) years. Seven hundred fifty-one (55.30 %) were women. Some 12.7 % of the patients had insomnia (ISI > 14), 9.6 % had excessive daytime sleepiness (ESS > 10), 46.5 % had poor sleep quality (PSQI > 5), and 354 patients (26.1 %) had depressive symptoms (BDI > 16). The mean QOLIE-10 score was 22.82 ± 8.14 (10-48). Resistant epilepsy was evaluated as the parameter with the highest risk affecting quality of life Adjusted odds ratio (AOR = 3.714; 95 % confidence interval (CI): [2.440-5.652] < 0.001)). ISI (AOR = 1.184; 95 % CI: [1.128-1.243]; p < 0.001), ESS (AOR = 1.081; 95 % CI: [1.034-1.130]; p < 0.001), PSQI (AOR = 0.928; 95 % CI: [0.867 - 0.994]; p = 0.034), BDI (AOR = 1.106; 95 % CI: [1.084-1.129]; p < 0.001), epilepsy duration (AOR = 1.023; 95 % CI: [1.004-1.041]; p = 0.014), were determined as factors affecting quality of life. Sleep disorders are common in PWE and impair their quality of life. Quality of life can be improved by controlling the factors that may cause sleep disorders such as good seizure control, avoiding polypharmacy, and correcting the underlying mood disorders in patients with epilepsy.