Changes of optical coherence tomographic hyperreflective foci in rhegmatogenous retinal detachment patients after successful surgery

• Published in: Photodiagnosis and photodynamic therapy Vol. 44; p. 103763
• Main Authors: Wu, Mengai, Chen, Lifeng, Lin, Li, Fan, Yuanyuan, Li, Haidong, Lian, Hengli, Zheng, Bin
• Format: Journal Article
• Language: English
• Published: Netherlands 01.12.2023
• Subjects: Humans; Photochemotherapy - methods; Photosensitizing Agents; Retinal Detachment - diagnostic imaging; Retinal Detachment - surgery; Retrospective Studies; Tomography, Optical Coherence - methods; Optical coherence tomographic; Rhegmatogenous retinal detachment; Hyperreflective foci
• ISSN: 1572-1000; 1873-1597
• DOI: 10.1016/j.pdpdt.2023.103763

To assess the changes of hyperreflective foci (HRF) in rhegmatogenous retinal detachment (RRD) patients after successful reattachment surgery. Twenty-nine macula-off RRD eyes with successful reattachment surgery were retrospectively analyzed. Optical coherence tomography (OCT) was used to image macular regions and measure HRF in outer retina and inner retina at 0.5, 1, 3, 6, 12 months after surgery. The relationships between HRF and photoreceptor layer status, visual outcomes were evaluated. After retinal reattachment, HRF mainly distributed at the location where external limiting membrane (ELM) or inner and outer segment (IS/OS) line was disrupted. The HRF numbers in outer and inner retina were greater in eyes with discontinuous IS/OS line than eyes with continuous IS/OS line (all p<0.05). In the outer retina,  HRF increased in the initial three months after retinal reattachment, and then decreased gradually after 3 months (p<0.05). The HRF number in the outer retina at postoperative 0.5 months was associated with favorable visual outcomes at 6 and 12 months (r=-0.487,  p =0.025; r=-0.626,  p=0.005, respectively), nevertheless, the HRF number at 3 months was correlated with poor visual results at 6 and 12 months (r=0.441,  p =0.017; r=0.477,  p=0.019, respectively). HRF mainly occurred near the site where ELM or IS/OS line was injured after retinal reattachment. In the outer retina, the number of HRF gradually increased in the first 3 months and then gradually decreased. The early appearance of HRF in the outer retina was associated with a good visual prognosis, while the late appearance may suggest a less favorable visual outcome.