The Relationship between HA-1 Compatibility and the Activation of Helper T Lymphocyte Precursors

The relationship between the compatibility in minor histocompatibility HA-1 antigen and the activation of helper (IL-2 producing) T lymphocyte precursors in vitro was studied in the group of 17 HLA-A2 positive HLA identical siblings.Although the number of pairs studied is still small, no correlation...

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Published inImmunobiology (1979) Vol. 203; no. 4; pp. 699 - 704
Main Authors Cukrova, V, Dobrovolna, M, Vrana, M, Dolezalova, L, Vitek, A, Loudova, M
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier GmbH 01.05.2001
Subjects
Acute Disease
Bone Marrow Transplantation - adverse effects
Bone Marrow Transplantation - immunology
Female
Graft vs Host Disease - etiology
Hematopoietic Stem Cells - immunology
histocompatibility antigen HLA
HLA-A2 Antigen - genetics
Humans
Lymphocyte Activation
Male
Minor Histocompatibility Antigens - genetics
Minor Histocompatibility Antigens - immunology
Nuclear Family
Oligopeptides - genetics
Oligopeptides - immunology
T-Lymphocytes, Helper-Inducer - immunology
BMT
HTLp
PCR-SSP
aGVHD
mH genes
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Summary:The relationship between the compatibility in minor histocompatibility HA-1 antigen and the activation of helper (IL-2 producing) T lymphocyte precursors in vitro was studied in the group of 17 HLA-A2 positive HLA identical siblings.Although the number of pairs studied is still small, no correlation has been found between HA-1 compatibility and helper T lymphocyte precursors activation.The results presented here could suggest the possibility that the HTLp assay does not have to be a relevant parameter for the detection of HA-1 mismatches in HLA identical siblings.
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ISSN:0171-2985
1878-3279
DOI:10.1016/S0171-2985(01)80018-8