Respiratory Difficulty after Use of Disopyramide

To the Editor: Disopyramide is gaining widespread acceptance as an antiarrhythmic drug. The proliferation of the use of this drug has been followed by several case reports of adverse reactions. Podrid et al. reported in the March 13 issue on the recurrence of congestive heart failure in 50 per cent...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 303; no. 10; p. 584
Main Authors Porterfield, J G, Antman, E M, Lown, B
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 04.09.1980
Subjects
Disopyramide - adverse effects
Drug Hypersensitivity - etiology
Heart Ventricles
Humans
Male
Middle Aged
Pyridines - adverse effects
Respiration Disorders - chemically induced
Tachycardia - drug therapy
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Summary:To the Editor: Disopyramide is gaining widespread acceptance as an antiarrhythmic drug. The proliferation of the use of this drug has been followed by several case reports of adverse reactions. Podrid et al. reported in the March 13 issue on the recurrence of congestive heart failure in 50 per cent of their patients treated with disopyramide. The negative inotropic effect of disopyramide was reported early, 1 but the frequency of its occurrence is only now being realized. We recently encountered a different type of adverse reaction to disopyramide while doing an acute drug test of the type described by Lown and . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198009043031016