S100B protein, glia and Gilles de la Tourette syndrome

Activated glial cells play an important role in a variety of neurological disorders. This study examines S100B protein levels in the serum of patients with Gilles de la Tourette syndrome, as potential marker for glial cell function. Two groups of children were examined: 61 reference patients and 33...

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Published inEuropean journal of paediatric neurology Vol. 5; no. 1; pp. 15 - 19
Main Authors van Passel, Ralph, Schlooz, Wim AJM, Lamers, Karel JB, Lemmens, Wim AJG, Rotteveel, Jan J
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.01.2001
Subjects
Adolescent
Adult
Biomarkers - blood
Calcium-Binding Proteins - blood
Child
Child, Preschool
Female
Gilles de la Tourette syndrome
Glial tissue
Humans
Male
Nerve Growth Factors - blood
Neuroglia - physiology
Reference Values
S100 Calcium Binding Protein beta Subunit
S100 Proteins
S100B protein
Tourette Syndrome - diagnosis
Tourette Syndrome - physiopathology
Glial tissue
Gilles de la Tourette syndrome
S100B protein
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Summary:Activated glial cells play an important role in a variety of neurological disorders. This study examines S100B protein levels in the serum of patients with Gilles de la Tourette syndrome, as potential marker for glial cell function. Two groups of children were examined: 61 reference patients and 33 patients with Gilles de la Tourette syndrome. It was found that S100B serum concentrations in the reference group decrease with increasing age. Furthermore it was found that the mean S100B concentration in serum of children with Gilles de la Tourette syndrome is significantly higher than in the reference group. These preliminary results suggest that glial tissue might be involved in the pathophysiology of the syndrome.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1090-3798
1532-2130
DOI:10.1053/ejpn.2001.0399