Continuous flow synthesis of C-acyloxy-substituted aziridines in microchannel reactor: Addition of carboxylic acids to 2-methylenaziridines

A microchannel reactor-based continuous flow method for synthesizing diverse C-acyloxy-substituted aziridines has been developed, allowing for rapid and efficient synthesis within seconds. [Display omitted] We have developed a novel microchannel reactor-based continuous flow method for synthesizing...

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Bibliographic Details
Published inTetrahedron letters Vol. 138; pp. 154982 - 154986
Main Authors Sun, Hao-Tian, Pan, Bin, Zhang, Shan-Shan, Su, Xian-Bin, Xu, Meng-Rui, Hu, Zi-Qing, Xu, Guang-Zhao
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 24.03.2024
Elsevier
Subjects
Aziridines
Carboxylic acids
Chemistry
Chemistry, Organic
Continuous flow
Methylenaziridines
Physical Sciences
Science & Technology
Methylenaziridines
Aziridines
Carboxylic acids
Continuous flow
AZIRINES
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Summary:A microchannel reactor-based continuous flow method for synthesizing diverse C-acyloxy-substituted aziridines has been developed, allowing for rapid and efficient synthesis within seconds. [Display omitted] We have developed a novel microchannel reactor-based continuous flow method for synthesizing diverse C-alkyl and C-aryl-acyloxyaziridines. This versatile approach is compatible with various substrates and functional groups, particularly for amino acids and carboxylic acid-containing active pharmaceutical ingredients, allowing for rapid and efficient synthesis within seconds.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2024.154982