A multifunctional drug delivery cargo: Folate-driven gold nanoparticle-vitamin B complex for next-generation drug delivery

•Successful synthesis and characterization of citrate-capped gold nanoparticles and functionalized conjugates.•Confirmation of nanoparticle formation through visual colour change and UV–Visible spectroscopy.•Identification of functional groups using FTIR analysis, validating conjugation of folate an...

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Bibliographic Details
Published inMaterials letters Vol. 355; p. 135425
Main Authors Samanta, Saptadip, Arivarasan, Vishnu Kirthi
Format Journal Article
LanguageEnglish
Published Elsevier B.V 15.01.2024
Subjects
Biomaterials
FTIR
Functional
Interfaces
Nanosize
Particles
Functional
Interfaces
Nanosize
FTIR
Particles
Biomaterials
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Summary:•Successful synthesis and characterization of citrate-capped gold nanoparticles and functionalized conjugates.•Confirmation of nanoparticle formation through visual colour change and UV–Visible spectroscopy.•Identification of functional groups using FTIR analysis, validating conjugation of folate and Vitamin B complex.•XRD analysis confirming crystalline structure of gold nanoparticles.•Particle size analysis demonstrating successful functionalization and potential for targeted drug delivery. The gold nanoparticles have manifold applications as drug delivery agents. The larger surface-to-volume ratio of the gold nanoparticles is the primary reason for their high drug-loading efficiency. Currently, their application is transitioning into nuclear medicines and as a theranostic assay of biological tissues. Bioactive gold nanoparticles have the potential to bind with growth factors such as Vitamins to regulate the cellular functions of different organs of the human body. The present study focuses on the formation of folate-functionalized gold nanoparticles conjugated Vitamin B complex. AuNPs were fabricated using thiol-linkage to conjugate folic acid and Vitamin B complex using heterobifunctional PEG derivative and characterized by UV–visible spectroscopy, FTIR, XRD analysis and Dynamic light scattering DLS. Thiol-linked folate functionalized AuNP-Vitamin B complex can act as a selective targeting molecule and exert a synergistic therapeutic effect as a multifunctional drug delivery system in nanomedicines.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2023.135425