Non-covalent complexes of polycationic/polyanionic fullerene C60 derivatives with cyanine dyes: Spectral properties and superoxide generation under NIR light irradiation

• Published in: Dyes and pigments Vol. 227; p. 112202
• Main Authors: Sizov, Lev R., Rybkin, Alexander Yu, Revina, Daria V., Kozlov, Alexei V., Kraevaya, Olga A., Troshin, Pavel A., Goryachev, Nikolay S.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.08.2024
• Subjects: Complexes; Cyanine dyes; Fullerene derivatives; Photodynamic therapy; Superoxide generation; Cyanine dyes; Superoxide generation; Photodynamic therapy; Fullerene derivatives; Complexes
• ISSN: 0143-7208; 1873-3743
• DOI: 10.1016/j.dyepig.2024.112202

Polycationic/polyanionic fullerene C60 derivatives and heptamethine cyanine dyes IR780, IR783, IR806, IR820 and piperazine-substituted derivative of IR780 dye form complexes through an electrostatic interaction in aqueous solutions. The fluorescence of the dye is strongly quenched in such complexes, and they efficiently generate superoxide anion-radical under near-infrared (NIR) irradiation due to the photoinduced electron transfer from the photoexcited dye to the fullerene core. The superoxide generation efficiency under NIR light irradiation increases 52 times for the IR783−(polycationic fullerene derivative) complex compared to the native dye. The demonstrated results show promising potential of such [cyanine dye]−fullerene structures as new NIR type I photosensitizers for the photodynamic therapy. [Display omitted] •Polycationic/polyanionic fullerene derivatives form complexes with cyanine dyes.•Such complexes are efficient superoxide generators under NIR light irradiation.•Structures [cyanine dye]−fullerene are promising NIR type I photosensitizers for PDT.