The synthesis and cognition enhancing effects of a series of dibenzoyl guanidines. Analogs of N,N′-[[4-(aminocarbonyl)phenyl]carbonimidoyl]bis[benzamide]

A series of both symmetrical and unsymmetrical dibenzoyl guanidines containing a p-aminobenzamide moiety was studied for the reversal of cognition deficits in rats and mice. The synthesis and biological activity of the title compounds is described.

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 2; no. 4; pp. 345 - 348
Main Authors Birnberg, G.H., Fanshawe, W.J., Levin, J.I., Epstein, J.W., Beer, B., Bartus, R.T., Dean, R.L.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 1992
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Summary:A series of both symmetrical and unsymmetrical dibenzoyl guanidines containing a p-aminobenzamide moiety was studied for the reversal of cognition deficits in rats and mice. The synthesis and biological activity of the title compounds is described.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80216-X