Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion

We sought to investigate the role of fibroblast growth factor (FGF)-1 during acute myocardial ischemia and reperfusion. The FGFs display cardioprotective effects during ischemia and reperfusion. We investigated FGF-1–induced cardioprotection during ischemia and reperfusion and the intracellular sign...

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Published inJournal of the American College of Cardiology Vol. 44; no. 5; pp. 1113 - 1123
Main Authors Palmen, Meindert, Daemen, Mat J.A.P., De Windt, Leon J., Willems, Jodil, Dassen, Willem R.M., Heeneman, Sylvia, Zimmermann, Rene, Van Bilsen, Marc, Doevendans, Pieter A.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.09.2004
Subjects
dP/dtmax
FGF
LVPdia
DMSO
PKC
HW/BW
dP/dtmin
MAPK
I/R
LVEDP
LDH
TG
LVDP
LVPsys
TK
AOF
IPC
WT
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Summary:We sought to investigate the role of fibroblast growth factor (FGF)-1 during acute myocardial ischemia and reperfusion. The FGFs display cardioprotective effects during ischemia and reperfusion. We investigated FGF-1–induced cardioprotection during ischemia and reperfusion and the intracellular signaling pathways responsible for these effects in an ex vivo murine setup of myocardial ischemia and reperfusion. Cardiac-specific human FGF-1 overexpression was associated with enhanced post-ischemic hemodynamic recovery and decreased lactate dehydrogenase release during reperfusion. Inhibition of the FGF receptor, protein kinase C (PKC), and tyrosine kinase (TK) resulted in blockade of FGF-1-induced protective effects on cardiac functional recovery and cell death. The overexpression of FGF-1 induces cardioprotection through a pathway that involves the FGF receptor, PKC, and TK.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2004.05.067