Reactive Oxygen Species Modulator 1 (ROMO1), a New Potential Target for Cancer Diagnosis and Treatment

• Published in: Chonnam medical journal Vol. 55; no. 3; pp. 136 - 143
• Main Authors: Amini, Mohammad Amin, Talebi, Seyed Saman, Karimi, Jamshid
• Format: Journal Article
• Language: English
• Published: Chonnam National University Medical School 01.09.2019; 의과학연구소
• Subjects: Review; 의학일반
• ISSN: 2233-7385; 2233-7393
• DOI: 10.4068/cmj.2019.55.3.136

Today, the incidence of cancer in the world is rising, and it is expected that in the next several decades, the number of people suffering from cancer or (the cancer rate) will double. Cancer is defined as the excessive and uncontrolled growth of cells; of course (in simple terms), cancer is considered to be a set of other diseases that ultimately causes normal cells to be transformed into neoplastic cells. One of the most important causes of the onset and exacerbation of cancer is excessive oxidative stress. One of the most important proteins in the inner membrane of mitochondria is Reactive Oxygen Species (ROS) Modulator 1 (ROMO1) that interferes with the production of ROS, and with increasing the rate of this protein, oxidative stress will increase, which ultimately leads to some diseases, especially cancer. In this overview, we use some global databases to provide information about ROMO1 cellular signaling pathways, their related proteins and molecules, and some of the diseases associated with the mitochondrial protein, especially cancer.