A General and Efficient CuBr2-Catalyzed N-Arylation of Secondary Acyclic Amides

A general and efficient Cu（II）-catalyzed cross-coupling method is reported for the preparation of acyclic tertiary amides. Generally moderate to excellent yields and functional group tolerance were obtained with secondary acyclic amides and aryl halides as substrates in toluene.

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Bibliographic Details
Published inChinese journal of chemistry Vol. 30; no. 10; pp. 2356 - 2362
Main Author 王满刚 于华 尤心稳 吴军 商志才
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.10.2012
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
Subjects
Amides
aryl halides
Chemistry
Chemistry, Multidisciplinary
copper
cross-coupling
Cu（II）
Halides
N-arylation
Physical Sciences
Science & Technology
Toluene
二级
交叉偶联
催化
芳基化反应
芳基卤化物
通用
酰胺
amides
N-arylation
C-N
AMIDATION
NUCLEOPHILES
IODIDES
CROSS-COUPLING REACTIONS
aryl halides
HETEROCYCLES
PHENOLS
cross-coupling
copper
LIGAND
COPPER CATALYST
Online AccessGet full text
ISSN1001-604X
1614-7065
DOI10.1002/cjoc.201200701

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Summary:A general and efficient Cu（II）-catalyzed cross-coupling method is reported for the preparation of acyclic tertiary amides. Generally moderate to excellent yields and functional group tolerance were obtained with secondary acyclic amides and aryl halides as substrates in toluene.
Bibliography:31-1547/O6
Wang, Mangang Yu, Hua You, Xinwen Wu, Jun Shang, Zhicai Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China
copper, N-arylation, cross-coupling, amides, aryl halides
A general and efficient Cu（II）-catalyzed cross-coupling method is reported for the preparation of acyclic tertiary amides. Generally moderate to excellent yields and functional group tolerance were obtained with secondary acyclic amides and aryl halides as substrates in toluene.
istex:40657E1403E44A6CB844BFA869C8C5A120EFBEE5
ark:/67375/WNG-5GBWQ5WM-N
ArticleID:CJOC201200701
the National Natural Science Foundation of China - No. 31071720
ObjectType-Article-1
SourceType-Scholarly Journals-1
content type line 14
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201200701