A novel protein encoded by circVPS13D attenuates antiviral innate immunity by targeting MAVS in teleost fish

The expression of circVPS13D was upregulated with SCRV invasion, which proved that circVPS13D was involved in the regulation of the antiviral immune response. Our study revealed that the existence of circVPS13D promoted the replication of SCRV. Functionally, circVPS13D negatively regulates the antiv...

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Published inJournal of virology Vol. 97; no. 11; p. e0088623
Main Authors Wang, Linchao, Song, Yanhong, Yan, Xiaolong, Xu, Tianjun
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 30.11.2023
Subjects
Animals
Cellular Response to Infection
Fish Diseases - immunology
Fish Diseases - metabolism
Fish Diseases - virology
Fish Proteins - genetics
Fishes - immunology
Fishes - virology
Immunity, Innate
RNA, Circular - metabolism
Signal Transduction
Vesicular Transport Proteins - genetics
Virus Diseases - immunology
Virus Diseases - metabolism
Virus Diseases - veterinary
Virus Diseases - virology
MAVS
ubiquitin-proteasome
antiviral immunity
circRNA
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Summary:The expression of circVPS13D was upregulated with SCRV invasion, which proved that circVPS13D was involved in the regulation of the antiviral immune response. Our study revealed that the existence of circVPS13D promoted the replication of SCRV. Functionally, circVPS13D negatively regulates the antiviral responses of fish. Mechanistically, we confirmed that circVPS13D inhibited RLRs antiviral signaling pathway via the encoded protein VPS13D-170aa by targeting MAVS. Our study provided novel insights into the roles of protein-coding circRNAs and supported VPS13D-170aa as a negative regulator in the antiviral immune responses of teleost fish.
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The authors declare no conflict of interest.
ISSN:0022-538X
1098-5514
1098-5514
DOI:10.1128/jvi.00886-23