A new efficient synthesis of both enantiomers of macrosphelide core: A potential precursor for functionalized macrosphelides

The asymmetric synthesis of a macrosphelide core (1) and its enantiomer was achieved from (S)- or (R)-3-hydroxybutyrate in excellent yields. These compounds are potentially useful precursors for the preparation of biologically important macrosphelide analogues.

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Bibliographic Details
Published inHeterocycles Vol. 59; no. 2; pp. 481 - 484
Main Authors Matsuya, Y, Kawaguchi, T, Nemoto, H, Nozaki, H, Hamada, H
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.03.2003
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
SEA HARE
MOLECULE
(+)-MACROSPHELIDE-A
INHIBITORS
CELL-CELL ADHESION
(+)-A
FORMAL TOTAL SYNTHESIS
ABSOLUTE STEREOSTRUCTURES
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Summary:The asymmetric synthesis of a macrosphelide core (1) and its enantiomer was achieved from (S)- or (R)-3-hydroxybutyrate in excellent yields. These compounds are potentially useful precursors for the preparation of biologically important macrosphelide analogues.
ISSN:0385-5414
1881-0942
DOI:10.3987/com-02-s68