Primary Creep Characterization in Porcine Lumbar Spine Subject to Repeated Loading

• Published in: Annals of biomedical engineering
• Main Authors: Morino, Concetta, Middleton, Shea, Op’t Eynde, Joost, Dimbath, Elizabeth, Kait, Jason, Luck, Jason, Bass, Cameron
• Format: Journal Article
• Language: English
• Published: United States 29.06.2024
• Subjects: Viscoelasticity; Lumbar flexion-compression; Repeated loading; Lumbar spine injury
• ISSN: 0090-6964; 1573-9686; 1573-9686
• DOI: 10.1007/s10439-024-03557-2

Low back pain (LBP) is a common medical condition worldwide, though the etiology of injuries causing most LBP is unknown. Flexion and repeated compression increase lumbar injury risk, yet the complex viscoelastic behavior of the lumbar spine has not been characterized under this loading scheme. Characterizing the non-injurious primary creep behavior in the lumbar spine is necessary for understanding the biomechanical response preceding injury. Fifteen porcine lumbar spinal units were loaded in repeated flexion-compression with peak compressive stresses ranging from 1.41 to 4.68 MPa. Applied loading simulated real loading exposures experienced by high-speed watercraft occupants. The strain response in the primary creep region was modeled for all tests using a generalized Kelvin-Voigt model. A quasilinear viscoelastic (QLV) approach was used to separate time-dependent (creep) and stress-dependent (elastic) responses. Optimizations between the models and experimental data determined creep time constants, creep coefficients, and elastic constants associated with this tissue under repeated flexion-compression loading. Average R for all fifteen models was 0.997. Creep time constants optimized across all fifteen models were 24 s and 580 s and contributed to 20 ± 3% and 30 ± 3% of the overall strain response, respectively. The non-transient behavior contributed to 50 ± 0% of the overall response. Elastic behavior for this porcine population had an average standard deviation of 24.5% strain across the applied stress range. The presented primary creep characterization provides the response precursor to injurious behavior in the lumbar spine. Results from this study can further inform lumbar injury prediction and kinematic models.