Perfluorocarbon-based O 2 nanocarrier for efficient photodynamic therapy
Tumor hypoxia is considered as one of the major factors that limit the efficiency of photodynamic therapy (PDT), in which oxygen (O ) is needed to generate singlet oxygen ( O ) for cell destruction. Inspired by the excellent O carrying ability of perfluorocarbon molecules in artificial blood, we pre...
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| Published in | Journal of materials chemistry. B, Materials for biology and medicine Vol. 7; no. 7; pp. 1116 - 1123 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
21.02.2019
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| Online Access | Get full text |
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| Summary: | Tumor hypoxia is considered as one of the major factors that limit the efficiency of photodynamic therapy (PDT), in which oxygen (O
) is needed to generate singlet oxygen (
O
) for cell destruction. Inspired by the excellent O
carrying ability of perfluorocarbon molecules in artificial blood, we prepared a series of polymer micelles with a perfluorocarbon core to carry both photo-sensitizer and O
to the tumor site, aiming to improve PDT efficiency. We found that the accelerated generation of
O
correlated with the increased perfluorocarbon amount in solution. In vitro cell study further showed that the new perfluorocarbon formulation not only improved the production of
O
, leading to enhanced photodynamic therapy efficiency, but also significantly reduced cell toxicity when compared with the one without these perfluoro units. This work provides a new option for improving PDT efficiency with the new perfluorocarbon-incorporated nanoplatform. |
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| ISSN: | 2050-750X 2050-7518 |
| DOI: | 10.1039/c8tb01844h |