POTENTIAL THERAPEUTIC VALUE OF DRUGS INHIBITING SEMICARBAZIDE-SENSITIVE AMINE OXIDASE: VASCULAR CYTOPROTECTION IN DIABETES MELLITUS
Semicarbazide-sensitive amine oxidase (SSAO) is a copper-containing enzyme found in large amounts in blood plasma and in vascular smooth muscle. The catalytic activity of this enzyme is elevated in diabetes mellitus and some substrates, such as aminoacetone and methylamine also occur in increased am...
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Published in | Pharmacological research Vol. 37; no. 2; pp. 87 - 92 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ltd
01.02.1998
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Subjects | |
Online Access | Get full text |
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Summary: | Semicarbazide-sensitive amine oxidase (SSAO) is a copper-containing enzyme found in large amounts in blood plasma and in vascular smooth muscle. The catalytic activity of this enzyme is elevated in diabetes mellitus and some substrates, such as aminoacetone and methylamine also occur in increased amounts in this disease. After deamination by SSAO highly angiotoxic products are formed, methylglyoxal and formaldehyde, respectively. Moreover, hydrogen peroxide is also formed as a side-product. These products arising from SSAO-catalysed reactions may partially explain late-diabetic damages in the kidneys, eyes and peripheral nerves, as well as other cardiovascular disorders. It is therefore proposed that inhibition of SSAO may decrease the formation of these cytotoxic products and therefore prevent or slow the development of late-diabetic complications. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1043-6618 1096-1186 |
DOI: | 10.1006/phrs.1997.0272 |