Prostate cancer detection using quantitative T 2 and T 2 -weighted imaging: The effects of 5-alpha-reductase inhibitors in men on active surveillance
T -weighted imaging (T -WI) information has been used in a qualitative manner in the assessment of prostate cancer. Quantitative derivatives (T relaxation time) can be generated from T -WI. These outputs may be useful in helping to discriminate clinically significant prostate cancer from background...
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Published in | Journal of magnetic resonance imaging Vol. 47; no. 6; pp. 1646 - 1653 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.06.2018
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Subjects | |
Online Access | Get full text |
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Summary: | T
-weighted imaging (T
-WI) information has been used in a qualitative manner in the assessment of prostate cancer. Quantitative derivatives (T
relaxation time) can be generated from T
-WI. These outputs may be useful in helping to discriminate clinically significant prostate cancer from background signal.
To investigate changes in quantitative T
parameters in lesions and noncancerous tissue of men on active surveillance for prostate cancer taking dutasteride 0.5 mg or placebo daily for 6 months.
Retrospective.
Forty men randomized to 6 months of daily dutasteride (n = 20) or placebo (n = 20).
Multiparametric 3T MRI at baseline and 6 months. This included a multiecho MR sequence for quantification of the T
relaxation times, in three regions of interest (index lesion, noncancerous peripheral [PZ] and transitional [TZ] zones). A synthetic signal contrast (T
Q contrast) between lesion and noncancerous tissue was assessed using quantitative T
values. Signal contrast was calculated using the T
-weighted sequence (T
W contrast).
Two radiologists reviewed the scans in consensus according to Prostate Imaging Reporting and Data System (PI-RADS v. 2) guidelines.
Wilcoxon and Mann-Whitney U-tests, Spearman's correlation.
When compared to noncancerous tissue, shorter T
values were observed within lesions at baseline (83.5 and 80.5 msec) and 6 months (81.5 and 81.9 msec) in the placebo and dutasteride arm, respectively. No significant differences for T
W contrast at baseline and after 6 months were observed, both in the placebo (0.40 [0.29-0.49] vs. 0.43 [0.25-0.49]; P = 0.881) and dutasteride arm (0.35 [0.24-0.47] vs. 0.37 [0.22-0.44]; P = 0.668). There was a significant, positive correlation between the T
Q contrast and the T
W contrast values (r = 0.786; P < 0.001).
The exposure to antiandrogen therapy did not significantly influence the T
contrast or the T
relaxation values in men on active surveillance for prostate cancer.
4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1646-1653. |
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ISSN: | 1053-1807 1522-2586 |
DOI: | 10.1002/jmri.25891 |